AK 295
Modify Date: 2026-08-15 16:25:41
AK 295 structure
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Common Name | AK 295 | ||
|---|---|---|---|---|
| CAS Number | 160399-35-9 | Molecular Weight | 504.62 | |
| Density | 1.145g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C26H40N4O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AK 295AK 295 (CX 295) is a calpain inhibitor that inhibits apoptosis through a calpain-dependent pathway. AK 295 improves neurological function in a rat model of spinal cord injury (SCI). AK 295 can be used in the study of neurodegenerative diseases, such as bulbar amyotrophy, stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis[1]. |
| Name | benzyl N-[(2S)-4-methyl-1-[[1-(3-morpholin-4-ylpropylamino)-1,2-dioxopentan-3-yl]amino]-1-oxopentan-2-yl]carbamate |
|---|---|
| Synonym | More Synonyms |
| Description | AK 295 (CX 295) is a calpain inhibitor that inhibits apoptosis through a calpain-dependent pathway. AK 295 improves neurological function in a rat model of spinal cord injury (SCI). AK 295 can be used in the study of neurodegenerative diseases, such as bulbar amyotrophy, stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis[1]. |
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| Related Catalog | |
| Target |
Calpain[1]. |
| References |
| Density | 1.145g/cm3 |
|---|---|
| Molecular Formula | C26H40N4O6 |
| Molecular Weight | 504.62 |
| Exact Mass | 504.29500 |
| PSA | 133.05000 |
| LogP | 3.00340 |
| Index of Refraction | 1.524 |
| InChIKey | TZVQRMYLYQNBOA-KEKNWZKVSA-N |
| SMILES | CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCCCN1CCOCC1 |
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Name: Inhibition of human liver cathepsin B
Source: ChEMBL
Target: Cathepsin B
External Id: CHEMBL1247361
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Name: Inhibition of porcine kidney calpain 2
Source: ChEMBL
Target: Calpain-2 catalytic subunit
External Id: CHEMBL1247360
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Name: Inhibition of porcine erythrocyte calpain 1
Source: ChEMBL
Target: Calpain-1 catalytic subunit
External Id: CHEMBL1247359
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Name: Drug level in C57BL/6 mouse heart at 24 mg/kg, iv after 1 hr by HPLC analysis
Source: ChEMBL
Target: Heart
External Id: CHEMBL1247369
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Name: Drug level in C57BL/6 mouse spleen at 24 mg/kg, sc after 1 hr by HPLC analysis
Source: ChEMBL
Target: Spleen
External Id: CHEMBL1247368
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Name: Drug level in C57BL/6 mouse serum at 24 mg/kg, sc after 1 hr by HPLC analysis
Source: ChEMBL
Target: Serum
External Id: CHEMBL1247367
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Name: Drug level in C57BL/6 mouse liver at 24 mg/kg, sc after 1 hr by HPLC analysis
Source: ChEMBL
Target: Liver
External Id: CHEMBL1247366
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Name: Drug level in C57BL/6 mouse kidney at 24 mg/kg, sc after 1 hr by HPLC analysis
Source: ChEMBL
Target: Kidney
External Id: CHEMBL1247365
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Name: Drug level in C57BL/6 mouse heart at 24 mg/kg, sc after 1 hr by HPLC analysis
Source: ChEMBL
Target: Heart
External Id: CHEMBL1247364
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Name: Selectivity ratio of Ki for porcine erythrocyte calpain 1 to Ki for human liver cathe...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1247362
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| AK 295 |
| Cbz-leu-abu-conh(CH2)3-mpl |
| CX 295 |
| Cbz-leu-aminobutyrate-conh(CH2)3-morpholine |