Bisandrographolide A

Modify Date: 2025-08-22 23:07:37

Bisandrographolide A Structure
Bisandrographolide A structure
Common Name Bisandrographolide A
CAS Number 160498-00-0 Molecular Weight 664.868
Density 1.2±0.1 g/cm3 Boiling Point 832.6±65.0 °C at 760 mmHg
Molecular Formula C40H56O8 Melting Point N/A
MSDS N/A Flash Point 252.3±27.8 °C

 Use of Bisandrographolide A


Bisandrographolide A (BAA) activates TRPV4 channel with an EC50 of 790-950 nM. Bisandrographolide A can bind to CD81 and suppress its function. Bisandrographolide A is an anti-inflammatory, immunostimulant, and antihypertensive compound[1][2].

 Names

Name Bisandrographolide A
Synonym More Synonyms

 Bisandrographolide A Biological Activity

Description Bisandrographolide A (BAA) activates TRPV4 channel with an EC50 of 790-950 nM. Bisandrographolide A can bind to CD81 and suppress its function. Bisandrographolide A is an anti-inflammatory, immunostimulant, and antihypertensive compound[1][2].
Related Catalog
Target

TRPV4 channel[1].

References

[1]. Yue GG, et al. Identification of active components in Andrographis paniculata targeting on CD81 in esophageal cancer in vitro and in vivo. Phytomedicine. 2022 Jul 20;102:154183.  

[2]. Vriens J, et al. Determinants of 4 alpha-phorbol sensitivity in transmembrane domains 3 and 4 of the cation channel TRPV4. J Biol Chem. 2007 Apr 27;282(17):12796-803.  

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 832.6±65.0 °C at 760 mmHg
Molecular Formula C40H56O8
Molecular Weight 664.868
Flash Point 252.3±27.8 °C
Exact Mass 664.397522
PSA 133.52000
LogP 3.82
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.596

 Synonyms

2(5H)-Furanone, 5-[2-[(1R,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]-1-(2,5-dihydro-2-oxo-3-furanyl)ethyl]-3-[(E)-2-[(1R,4aS,5R,6R,8aR)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethenyl]-
5-{2-[(1R,4aS,5R,6R,8aS)-6-Hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydro-1-naphthalenyl]-1-(2-oxo-2,5-dihydro-3-furanyl)ethyl}-3-{(E)-2-[(1R,4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydro-1-naphthalenyl]vinyl}-2(5H)-furanone
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