Amt-87

Modify Date: 2024-04-11 23:10:10

Amt-87 Structure
Amt-87 structure
Common Name Amt-87
CAS Number 1609019-52-4 Molecular Weight 492.612
Density N/A Boiling Point N/A
Molecular Formula C30H36O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Amt-87


Amt-87 is a HIV latency-reversal agent that reactivates latent HIV at the transcriptional level, promotes phosphorylation of CDK9 T-loop at Thr186; induces P-TEFb dissociation from 7SK snRNP and promotes Tat-SEC formation on HIV-1 LTR, dissociates P-TEFb from 7SK snRNP and promotes Tat-SEC formation at the HIV-1 promoter; synergizes with prostratin and JQ1 to reverse HIV latency and reactivate viral transcription.

 Names

Name Amt-87

 Amt-87 Biological Activity

Description Amt-87 is a HIV latency-reversal agent that reactivates latent HIV at the transcriptional level, promotes phosphorylation of CDK9 T-loop at Thr186; induces P-TEFb dissociation from 7SK snRNP and promotes Tat-SEC formation on HIV-1 LTR, dissociates P-TEFb from 7SK snRNP and promotes Tat-SEC formation at the HIV-1 promoter; synergizes with prostratin and JQ1 to reverse HIV latency and reactivate viral transcription.
References References 1. Wu J, et al. Sci Rep. 2017 Sep 6;7(1):10657. View Related Products by Target Cyclin-dependent Kinase (CDK)

 Chemical & Physical Properties

Molecular Formula C30H36O6
Molecular Weight 492.612
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