1609019-52-4
1609019-52-4 structure
- Name: Amt-87
- Chemical Name: Amt-87
- CAS Number: 1609019-52-4
- Molecular Formula: C30H36O6
- Molecular Weight: 492.612
- Create Date: 2020-01-19 21:11:51
- Modify Date: 2024-04-11 23:10:10
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Amt-87 is a HIV latency-reversal agent that reactivates latent HIV at the transcriptional level, promotes phosphorylation of CDK9 T-loop at Thr186; induces P-TEFb dissociation from 7SK snRNP and promotes Tat-SEC formation on HIV-1 LTR, dissociates P-TEFb from 7SK snRNP and promotes Tat-SEC formation at the HIV-1 promoter; synergizes with prostratin and JQ1 to reverse HIV latency and reactivate viral transcription.
| Name | Amt-87 |
|---|
| Description | Amt-87 is a HIV latency-reversal agent that reactivates latent HIV at the transcriptional level, promotes phosphorylation of CDK9 T-loop at Thr186; induces P-TEFb dissociation from 7SK snRNP and promotes Tat-SEC formation on HIV-1 LTR, dissociates P-TEFb from 7SK snRNP and promotes Tat-SEC formation at the HIV-1 promoter; synergizes with prostratin and JQ1 to reverse HIV latency and reactivate viral transcription. |
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| References | References 1. Wu J, et al. Sci Rep. 2017 Sep 6;7(1):10657. View Related Products by Target Cyclin-dependent Kinase (CDK) |
| Molecular Formula | C30H36O6 |
|---|---|
| Molecular Weight | 492.612 |