CD31
Modify Date: 2025-08-24 21:31:50
CD31 structure
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Common Name | CD31 | ||
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| CAS Number | 161374-99-8 | Molecular Weight | 2601.10 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C119H202N36O29 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CD31CD31 (PECAM-1) is platelet endothelial cell adhesion molecule-1, serves as the endothelial cell-specific receptor of clostridium perfringens b-Toxin (CPB). CD31 is also an ER-MP12 antigen, acts as a linker between mechanical stress, metabolism and inflammation. CD31 peptide is able to sustain phosphorylation of the CD31 ITIM686 and of SHP2 and to inhibit TCR-induced T-cell activation[1]-[5]. |
| Name | CD31 |
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| Description | CD31 (PECAM-1) is platelet endothelial cell adhesion molecule-1, serves as the endothelial cell-specific receptor of clostridium perfringens b-Toxin (CPB). CD31 is also an ER-MP12 antigen, acts as a linker between mechanical stress, metabolism and inflammation. CD31 peptide is able to sustain phosphorylation of the CD31 ITIM686 and of SHP2 and to inhibit TCR-induced T-cell activation[1]-[5]. |
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| Related Catalog | |
| In Vitro | CD31 is a trans-homophilic co-signaling protein at the crossroad between mechanical stress, metabolism and inflammation[1]. CD31 is a ER-MP12 antigen, exerts function as promoting cell adhesion between endothelial cells, enabling transmigration of leukocytes across vascular endothelium, and producing signaling to up-regulation of other adhesion molecules in neighboring cells[2]. Clostridium perfringens b-toxin (CPB) is a highly active b-pore-forming toxin (b-PFT) and the essential virulence factor for fatal, necro-hemorrhagic enteritis[3]. CD31 serves as the specific membrane receptor for clostridium perfringens b-toxin (CPB) on endothelial cells. CD31 directly interacts with CPB, with the membrane proximal Ig6 domain[3]. CD31 also serves as a therapeutic target in atherosclerosis[4]. CD31 (0, 25, 50, 100 μg/mL) induces proliferative response to TCR engagement of human PBMCs in a dose-dependent manner[5]. |
| References |
| Molecular Formula | C119H202N36O29 |
|---|---|
| Molecular Weight | 2601.10 |