Carbobenzyloxy-Val-Ala-Asp-alpha-fluoromethylketone
Modify Date: 2024-01-11 17:36:22
Carbobenzyloxy-Val-Ala-Asp-alpha-fluoromethylketone structure
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Common Name | Carbobenzyloxy-Val-Ala-Asp-alpha-fluoromethylketone | ||
|---|---|---|---|---|
| CAS Number | 161401-82-7 | Molecular Weight | 453.461 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 758.0±60.0 °C at 760 mmHg | |
| Molecular Formula | C21H28FN3O7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 412.2±32.9 °C | |
Use of Carbobenzyloxy-Val-Ala-Asp-alpha-fluoromethylketoneZ-VAD-FMK (Z-VAD(OH)-FMK) is a well-know pan caspase inhibitor, which does not inhibit ubiquitin carboxy-terminal hydrolase L1 (UCHL1) activity even at concentrations as high as 440 μM[1]. |
| Name | (3S)-5-fluoro-3-[[(2S)-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]propanoyl]amino]-4-oxopentanoic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Z-VAD-FMK (Z-VAD(OH)-FMK) is a well-know pan caspase inhibitor, which does not inhibit ubiquitin carboxy-terminal hydrolase L1 (UCHL1) activity even at concentrations as high as 440 μM[1]. |
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| Related Catalog | |
| Target |
Caspase |
| In Vitro | Z-VAD-FMK (40 μM) reverses the apoptotic effect exerted by total saponin of Solanum lyratum Thunb (TSSLT) in Hela cells. HeLa cells are pretreated with Z-VAD-FMK (40 μM) for 30 min and exposed to TSSLT (6 μg/mL) for 48 h[2]. Cell Viability Assay[2] Cell Line: HeLa cells Concentration: 40 μM Incubation Time: Prtreated for 30 minutes Result: Prevented TSSLT-induced cell death. More than 80% cell survival was observed. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 758.0±60.0 °C at 760 mmHg |
| Molecular Formula | C21H28FN3O7 |
| Molecular Weight | 453.461 |
| Flash Point | 412.2±32.9 °C |
| Exact Mass | 453.191132 |
| PSA | 161.37000 |
| LogP | 3.04 |
| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
| Index of Refraction | 1.525 |
| Hazard Codes | Xi |
|---|
| Z-VAD-FMK,Non-methylated |
| Z-Val-Ala-Asp-FMK |
| Caspase Inhibitor VI |
| N-[(Benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxo-2-butanyl]-L-alaninamide |
| L-alaninamide,N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-1-(carboxymethyl)-3-fluoro-2-oxopropyl] |
| (3S)-3-[(2S)-2-[(2S)-2-{[(benzyloxy)carbonyl]amino}-3-methylbutanamido]propanamido]-5-fluoro-4-oxopentanoic acid |
| L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-1-(carboxymethyl)-3-fluoro-2-oxopropyl]- |
| N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Z-VAD-FMK
- Price: Click To Check
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: Z-VAD(OH)-FMK
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: Z-VAD(OH)-FMK
- Price: $3200.0/250mg
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- Nanjing Peptide Biotech Ltd
- China
- Product Name: Carbobenzyloxy-Val-Ala-Asp-alpha-fluoromethylketone
- Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
- Purity: 98.0%
- Delivery: 7 Day
- Contact: jom
- Email: chenglong.fan@njpeptide.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Z-Vad-fmk, non-methylated
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
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Price: ￥3090/10 mM * 1 mL in DMSO
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