Cyclo(-Arg-Gly-Asp-D-Phe-Lys) trifluoroacetate salt structure
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Common Name | Cyclo(-Arg-Gly-Asp-D-Phe-Lys) trifluoroacetate salt | ||
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CAS Number | 161552-03-0 | Molecular Weight | 603.670 | |
Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
Molecular Formula | C27H41N9O7 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of Cyclo(-Arg-Gly-Asp-D-Phe-Lys) trifluoroacetate saltCyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM. Sequence: Cyclo(Arg-Gly-Asp-Phe-Lys). |
Name | 2-[(2S,5R,8S,11S)-8-(4-aminobutyl)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid |
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Synonym | More Synonyms |
Description | Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM. Sequence: Cyclo(Arg-Gly-Asp-Phe-Lys). |
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Related Catalog | |
Target |
IC50: 0.94 nM (αvβ3 integrin)[1]. |
In Vitro | Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with a IC50 of 0.94 nM[1]. [(66)Ga]DOTA-E-[c(RGDfK)]2 can be prepared with high radiochemical purity (>97%), specific activity (36-67GBq/μM), in vitro stability, and moderate protein binding. MicroPET imaging up to 24 post-injection showed contrasting tumors reflecting αvβ3-targeted tracer accumulation[2]. |
References |
Density | 1.5±0.1 g/cm3 |
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Molecular Formula | C27H41N9O7 |
Molecular Weight | 603.670 |
Exact Mass | 603.312866 |
PSA | 288.17000 |
LogP | -3.10 |
Index of Refraction | 1.666 |
Storage condition | -20°C |
~% Cyclo(-Arg-Gly-... CAS#:161552-03-0 |
Literature: Petersen, Svea; Alonso, Jose Maria; Specht, Alexandre; Duodu, Portia; Goeldner, Maurice; Del Campo, Aranzazu Angewandte Chemie - International Edition, 2008 , vol. 47, # 17 p. 3192 - 3195 |
~% Cyclo(-Arg-Gly-... CAS#:161552-03-0 |
Literature: Boturyn, Didier; Dumy, Pascal Tetrahedron Letters, 2001 , vol. 42, # 15 p. 2787 - 2790 |
~% Cyclo(-Arg-Gly-... CAS#:161552-03-0 |
Literature: Boturyn, Didier; Dumy, Pascal Tetrahedron Letters, 2001 , vol. 42, # 15 p. 2787 - 2790 |
~% Cyclo(-Arg-Gly-... CAS#:161552-03-0 |
Literature: Boturyn, Didier; Dumy, Pascal Tetrahedron Letters, 2001 , vol. 42, # 15 p. 2787 - 2790 |
~% Cyclo(-Arg-Gly-... CAS#:161552-03-0 |
Literature: Boturyn, Didier; Dumy, Pascal Tetrahedron Letters, 2001 , vol. 42, # 15 p. 2787 - 2790 |
Cyclo (-RGDfK) |
c(D-Phe-Lys-Arg-Gly-Asp) |
A8164 |
Cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-L-lysyl) |
cyclo-[Arg-Gly-Asp-D-Phe-Lys] |
Cyclo[L-α-aspartyl-D-phenylalanyl-L-lysyl-N-(diaminomethylene)-L-ornithylglycyl] |
cyclic-RGD peptide |
cyclo[RGD-{D-F}-K] |
cyclo(RGDfK) |
Cyclo-RGDfK |