FMOC-ASP(OTBU)-OH

Modify Date: 2024-01-03 01:07:59

FMOC-ASP(OTBU)-OH Structure
FMOC-ASP(OTBU)-OH structure
Common Name FMOC-ASP(OTBU)-OH
CAS Number 71989-14-5 Molecular Weight 411.448
Density 1.3±0.1 g/cm3 Boiling Point 620.8±55.0 °C at 760 mmHg
Molecular Formula C23H25NO6 Melting Point 148-150 °C (dec.)
MSDS Chinese USA Flash Point 329.3±31.5 °C

 Use of FMOC-ASP(OTBU)-OH


Fmoc-Asp(OtBu)-OH (4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate) is a aspartate derivative containing amine protecting group Fmoc. Fmoc-Asp(OtBu)-OH can be used for peptide synthesis[1].

 Names

Name FMOC-L-Aspartic acid β-tert-butyl ester
Synonym More Synonyms

 FMOC-ASP(OTBU)-OH Biological Activity

Description Fmoc-Asp(OtBu)-OH (4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate) is a aspartate derivative containing amine protecting group Fmoc. Fmoc-Asp(OtBu)-OH can be used for peptide synthesis[1].
Related Catalog
References

[1]. Esquivel J B, et al. Chiral HPLC separation of protected amino acids. Journal of liquid chromatography & related technologies, 1998, 21(6): 777-791.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 620.8±55.0 °C at 760 mmHg
Melting Point 148-150 °C (dec.)
Molecular Formula C23H25NO6
Molecular Weight 411.448
Flash Point 329.3±31.5 °C
Exact Mass 411.168182
PSA 101.93000
LogP 5.16
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.576
Storage condition 2~8°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2924299090

 Synthetic Route

~62%

FMOC-ASP(OTBU)-OH Structure

FMOC-ASP(OTBU)-OH

CAS#:71989-14-5

Literature: Nowshuddin, Shaik; Rao; Reddy, A. Ram Synthetic Communications, 2009 , vol. 39, # 11 p. 2022 - 2031

~78%

FMOC-ASP(OTBU)-OH Structure

FMOC-ASP(OTBU)-OH

CAS#:71989-14-5

Literature: Schoen, Istvan; Kisfaludy, Lajos Synthesis, 1986 , # 4 p. 303 - 305

~62%

FMOC-ASP(OTBU)-OH Structure

FMOC-ASP(OTBU)-OH

CAS#:71989-14-5

Literature: Henklein, Peter; Heyne, Hans-Ulrich; Halatsch, Wolf-Rainer; Niedrich, Hartmut Synthesis, 1987 , # 2 p. 166 - 167

~68%

FMOC-ASP(OTBU)-OH Structure

FMOC-ASP(OTBU)-OH

CAS#:71989-14-5

Literature: Echner, Hartmut; Voelter, Wolfgang Liebigs Annalen der Chemie, 1988 , p. 1095 - 1098

~%

FMOC-ASP(OTBU)-OH Structure

FMOC-ASP(OTBU)-OH

CAS#:71989-14-5

Literature: Journal of Organic Chemistry, , vol. 77, # 23 p. 10575 - 10582

~%

FMOC-ASP(OTBU)-OH Structure

FMOC-ASP(OTBU)-OH

CAS#:71989-14-5

Literature: Synthesis, , # 2 p. 166 - 167

~%

FMOC-ASP(OTBU)-OH Structure

FMOC-ASP(OTBU)-OH

CAS#:71989-14-5

Detail
Literature: Synthesis, , # 7 p. 571 - 572

~%

FMOC-ASP(OTBU)-OH Structure

FMOC-ASP(OTBU)-OH

CAS#:71989-14-5

Literature: Tetrahedron Letters, , vol. 34, # 2 p. 323 - 326

~%

FMOC-ASP(OTBU)-OH Structure

FMOC-ASP(OTBU)-OH

CAS#:71989-14-5

Literature: Synthesis, , # 2 p. 166 - 167

 Customs

HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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 Synonyms

L-Aspartic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 4-(1,1-dimethylethyl) ester
FMOC-L-Asparticacidbeta-tert-butylester
4-tert-Butyl hydrogen N-((9H-fluoren-9-ylmethoxy)carbonyl)-L-aspartate
(2S)-2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-4-[(2-methyl-2-propanyl)oxy]-4-oxobutanoic acid
MFCD00037131
FMOC-L-Aspartic acid beta-tert-butyl ester
N-α-FMOC-L-aspartic acid β-tert-butyl ester
Fmoc-L-aspartic acid 4-tert-butyl ester
Fmoc-Asp(OtBu)-OH
EINECS 276-251-7
(2S)-4-tert-Butoxy-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-4-oxobutanoic acid (non-preferred name)
9-fluorenyl-methoxycarbonyl-L-Asp-tert-butyl ester
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