L-372662
Modify Date: 2024-01-12 21:45:42
L-372662 structure
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Common Name | L-372662 | ||
|---|---|---|---|---|
| CAS Number | 162045-26-3 | Molecular Weight | 586.68 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 810.8±65.0 °C at 760 mmHg | |
| Molecular Formula | C33H38N4O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 444.2±34.3 °C | |
Use of L-372662L-372662 is a potent and orally active non-peptide oxytocin antagonist with a Ki value of 4.8. The Kd value of L-372662 for wild-type hOTR and [A318G]OTR is 5.8 nM and 73 nM. L-372662 shows selectivity to OTR:V1aR[1][2]. |
| Name | L-372662 |
|---|---|
| Synonym | More Synonyms |
| Description | L-372662 is a potent and orally active non-peptide oxytocin antagonist with a Ki value of 4.8. The Kd value of L-372662 for wild-type hOTR and [A318G]OTR is 5.8 nM and 73 nM. L-372662 shows selectivity to OTR:V1aR[1][2]. |
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| Related Catalog | |
| Target |
Ki: 4.8 (oxytocin)[1][2] |
| In Vivo | L-372662 is an antagonist of oxytocin-induced uterine contractions in late gestation pregnant rhesus monkeys (AD50 = 36 micrograms/kg), oral bioavailability (F = 90% in dogs), and aqueous solubility (10 mg/mL). |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 810.8±65.0 °C at 760 mmHg |
| Molecular Formula | C33H38N4O6 |
| Molecular Weight | 586.68 |
| Flash Point | 444.2±34.3 °C |
| Exact Mass | 586.279114 |
| LogP | 2.07 |
| Vapour Pressure | 0.0±2.9 mmHg at 25°C |
| Index of Refraction | 1.647 |
| L-372662 |
| 2H-3,1-Benzoxazin-2-one, 1,4-dihydro-1-[1-[2-methoxy-4-[[1-[(2-methyl-1-oxido-3-pyridinyl)methyl]-4-piperidinyl]oxy]benzoyl]-4-piperidinyl]- |
| 1-{1-[2-Methoxy-4-({1-[(2-methyl-1-oxido-3-pyridinyl)methyl]-4-piperidinyl}oxy)benzoyl]-4-piperidinyl}-1,4-dihydro-2H-3,1-benzoxazin-2-one |
| 1-{1-[2-methoxy-4-({1-[(2-methyl-1-oxidopyridin-3-yl)methyl]piperidin-4-yl}oxy)benzoyl]piperidin-4-yl}-1,4-dihydro-2H-3,1-benzoxazin-2-one |
| MFCD00936338 |