PFI-2
Modify Date: 2024-01-02 17:33:44
PFI-2 structure
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Common Name | PFI-2 | ||
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| CAS Number | 1627676-59-8 | Molecular Weight | 499.522 | |
| Density | 1.371±0.06 g/cm3 | Boiling Point | 642.7±65.0 °C at 760 mmHg | |
| Molecular Formula | C23H25F4N3O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 342.5±34.3 °C | |
Use of PFI-2PFI-2 is a a first-in-class, potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 with IC50 of 2 nM, 500 fold active than (S)-PFI-2.IC50 value: 2 nM [1]Target: SETD7(R)-PFI-2 is highly selective (>1,000-fold) for SETD7, over a panel of 18 other human protein methyltransferases and DNMT1, and was shown to be inactive against 134 additional ion channel, GPCR, and enzyme targets (<35% inhibition at 10 μM). (R)-PFI-2 binds to SETD7 only in the presence of SAM. PFI-766, a biotinylated variant of (R)-PFI-2 that retains the ability to bind and inhibit SETD7 (IC50 110 ± 26 nM in our in vitro enzymatic assay). PFI-766 engagement of endogenous SETD7 was also confirmed by mass spectrometry that supported the high specificity of the compound for endogenous SETD7. |
| Name | 6-Isoquinolinesulfonamide, 8-fluoro-1,2,3,4-tetrahydro-N-[(1R)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]- |
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| Synonym | More Synonyms |
| Description | PFI-2 is a a first-in-class, potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 with IC50 of 2 nM, 500 fold active than (S)-PFI-2.IC50 value: 2 nM [1]Target: SETD7(R)-PFI-2 is highly selective (>1,000-fold) for SETD7, over a panel of 18 other human protein methyltransferases and DNMT1, and was shown to be inactive against 134 additional ion channel, GPCR, and enzyme targets (<35% inhibition at 10 μM). (R)-PFI-2 binds to SETD7 only in the presence of SAM. PFI-766, a biotinylated variant of (R)-PFI-2 that retains the ability to bind and inhibit SETD7 (IC50 110 ± 26 nM in our in vitro enzymatic assay). PFI-766 engagement of endogenous SETD7 was also confirmed by mass spectrometry that supported the high specificity of the compound for endogenous SETD7. |
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| Related Catalog | |
| References |
| Density | 1.371±0.06 g/cm3 |
|---|---|
| Boiling Point | 642.7±65.0 °C at 760 mmHg |
| Molecular Formula | C23H25F4N3O3S |
| Molecular Weight | 499.522 |
| Flash Point | 342.5±34.3 °C |
| Exact Mass | 499.155273 |
| PSA | 86.89000 |
| LogP | 3.55 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.566 |
| Storage condition | 2-8℃ |
| Water Solubility | Practically insoluble (0.06 g/L) (25 ºC) |
| 6-Isoquinolinesulfonamide, 8-fluoro-1,2,3,4-tetrahydro-N-[(1R)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]- |
| 8-Fluoro-N-{(2R)-1-oxo-1-(1-pyrrolidinyl)-3-[3-(trifluoromethyl)phenyl]-2-propanyl}-1,2,3,4-tetrahydro-6-isoquinolinesulfonamide |
| PFI-2 |
| 8-Fluoro-1,2,3,4-tetrahydro-N-[(1R)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]-6-isoquinolinesulfonamide |