Chromanol 293B
Chromanol 293B structure
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Common Name | Chromanol 293B | ||
|---|---|---|---|---|
| CAS Number | 163163-23-3 | Molecular Weight | 324.39500 | |
| Density | 1.33g/cm3 | Boiling Point | 474.1ºC at 760mmHg | |
| Molecular Formula | C15H20N2O4S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Chromanol 293BChromanol 293B is a selective blocker of the slow delayed rectifier K+ current (IKs) with IC50 of 1-10 μM and a weak inhibitor of KATP channel. Chromanol 293B also blocks the CFTR chloride current with an IC50 of 19 μM[1]. |
| Name | N-[(3R,4S)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-N-methylethanesulfonamide |
|---|---|
| Synonym | More Synonyms |
| Description | Chromanol 293B is a selective blocker of the slow delayed rectifier K+ current (IKs) with IC50 of 1-10 μM and a weak inhibitor of KATP channel. Chromanol 293B also blocks the CFTR chloride current with an IC50 of 19 μM[1]. |
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| Related Catalog | |
| References |
| Density | 1.33g/cm3 |
|---|---|
| Boiling Point | 474.1ºC at 760mmHg |
| Molecular Formula | C15H20N2O4S |
| Molecular Weight | 324.39500 |
| Exact Mass | 324.11400 |
| PSA | 99.01000 |
| LogP | 2.49358 |
| Vapour Pressure | 8.52E-10mmHg at 25°C |
| Index of Refraction | 1.592 |
| InChIKey | HVSJHHXUORMCGK-UONOGXRCSA-N |
| SMILES | CCS(=O)(=O)N(C)C1c2cc(C#N)ccc2OC(C)(C)C1O |
| Storage condition | 20°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H312-H332 |
| Precautionary Statements | P280 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R20/21/22 |
| Safety Phrases | S36/37 |
| RIDADR | NONH for all modes of transport |
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Genetic Inhibition Of The Ubiquitin Ligase Rnf5 Attenuates Phenotypes Associated To F508del Cystic Fibrosis Mutation.
Sci. Rep. 5 , 12138, (2015) Cystic fibrosis (CF) is caused by mutations in the CFTR chloride channel. Deletion of phenylalanine 508 (F508del), the most frequent CF mutation, impairs CFTR trafficking and gating. F508del-CFTR mist... |
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Drosophila KCNQ channel displays evolutionarily conserved electrophysiology and pharmacology with mammalian KCNQ channels.
PLoS ONE 6(9) , e23898, (2011) Of the five human KCNQ (Kv7) channels, KCNQ1 with auxiliary subunit KCNE1 mediates the native cardiac I(Ks) current with mutations causing short and long QT cardiac arrhythmias. KCNQ4 mutations cause ... |
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Effects of KCNQ channel modulators on the M-type potassium current in primate retinal pigment epithelium.
Am. J. Physiol. Cell Physiol. 302(5) , C821-33, (2012) Recently, we demonstrated the expression of KCNQ1, KCNQ4, and KCNQ5 transcripts in monkey retinal pigment epithelium (RPE) and showed that the M-type current in RPE cells is blocked by the specific KC... |
| MFCD06798368 |
| Chromanol 293B |
| 293B Cpd |