MAZ51
Modify Date: 2024-02-01 12:38:21
MAZ51 structure
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Common Name | MAZ51 | ||
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| CAS Number | 163655-37-6 | Molecular Weight | 314.380 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 553.9±50.0 °C at 760 mmHg | |
| Molecular Formula | C21H18N2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 288.8±30.1 °C | |
Use of MAZ51MAZ51 is a selective inhibitor of VEGFR-3 (Flt-4) tyrosine kinase. MAZ51 inhibits VEGF-C-induced activation of VEGFR-3 without blocking VEGF-C-mediated stimulation of VEGFR2. MAZ51 had no effect on ligand-induced autophosphorylation of EGFR, IGF-1R and PDGFRβ. MAZ51 blocks proliferation and induces apoptosis in a wide variety of tumor cells. Antitumor activity[1][2]. |
| Name | maz51 |
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| Synonym | More Synonyms |
| Description | MAZ51 is a selective inhibitor of VEGFR-3 (Flt-4) tyrosine kinase. MAZ51 inhibits VEGF-C-induced activation of VEGFR-3 without blocking VEGF-C-mediated stimulation of VEGFR2. MAZ51 had no effect on ligand-induced autophosphorylation of EGFR, IGF-1R and PDGFRβ. MAZ51 blocks proliferation and induces apoptosis in a wide variety of tumor cells. Antitumor activity[1][2]. |
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| Related Catalog | |
| Target |
VEGFR3 |
| In Vitro | MAZ51 (2.5-10 μM; 24 hours) blocks proliferation and induces apoptosis in a wide variety of tumor cells[2]. MAZ51 (0.5-50 μM; 25 minutes) has no effect on ligand-induced autophosphorylation of EGFR, IGF-1R and PDGFRβ in A431 cells, HEK-293 cells, and PAE cells, respectively[2]. Cell Proliferation Assay[2] Cell Line: MT450, 1AS, ASM, G, AT6.1, MTLN3, MTLY, NM-081 cells Concentration: 2.5, 10 μM Incubation Time: 24 hours Result: Induced apoptosis in a wide variety of tumor cells. Apoptosis Analysis[2] Cell Line: MT450, 1AS, ASM, G, AT6.1, MTLN3, MTLY, NM-081 cells Concentration: 2.5, 10 μM Incubation Time: 24 hours Result: Blocked proliferation in a wide variety of tumor cells. |
| In Vivo | MAZ51 (8 mg/kg; i.p.; daily for 15 day) significantly suppresses the growth of MT450 tumors[2]. Animal Model: Wistar Furth rats (bearing MT450 cells)[1] Dosage: 8 mg/kg Administration: Intraperitoneal injection; daily for 15 day Result: Significantly suppressed the growth of MT450 tumors. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 553.9±50.0 °C at 760 mmHg |
| Molecular Formula | C21H18N2O |
| Molecular Weight | 314.380 |
| Flash Point | 288.8±30.1 °C |
| Exact Mass | 314.141907 |
| PSA | 32.34000 |
| LogP | 5.15 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.729 |
| Hazard Codes | Xn: Harmful;N: Dangerous for the environment; |
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| Risk Phrases | R22 |
| Safety Phrases | S26 |
| RIDADR | UN 3077 9/PG 3 |
| HS Code | 2933790090 |
| HS Code | 2933790090 |
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| Summary | 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0% |
| 2H-Indol-2-one, 3-[[4-(dimethylamino)-1-naphthalenyl]methylene]-1,3-dihydro-, (3Z)- |
| MFCD04036983 |
| 3-(4-dimethylamino-naphthalen-1-ylmethylene)-1,3-dihydro-indol-2-one |
| (3Z)-3-{[4-(Dimethylamino)-1-naphthyl]methylene}-1,3-dihydro-2H-indol-2-one |
| 3-(4-Dimethylaminonaphthalen-1-ylmethylene)-1,3-dihydroindol-2-one |