Cangrelor tetrasodium
Modify Date: 2024-01-11 20:06:53
Cangrelor tetrasodium structure
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Common Name | Cangrelor tetrasodium | ||
|---|---|---|---|---|
| CAS Number | 163706-36-3 | Molecular Weight | 864.286 | |
| Density | N/A | Boiling Point | 979ºC at 760 mmHg | |
| Molecular Formula | C17H21Cl2F3N5Na4O12P3S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 545.9ºC | |
Use of Cangrelor tetrasodiumCangrelor tetrasodium, an adenosine triphosphate analogue, is a reversible and selective platelet P2Y12 antagonist, with prompt and potent antiplatelet effects. Cangrelor tetrasodium directly blocks adenosine diphosphate (ADP)-induced activation and aggregation of platelets. Cangrelor tetrasodium is also a nonspecific GPR17 antagonist[1][2]. |
| Name | tetrasodium,[dichloro(phosphonato)methyl]-[[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(2-methylsulfanylethylamino)-2-(3,3,3-trifluoropropylsulfanyl)purin-9-yl]oxolan-2-yl]methoxy-oxidophosphoryl]oxyphosphinate |
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| Synonym | More Synonyms |
| Description | Cangrelor tetrasodium, an adenosine triphosphate analogue, is a reversible and selective platelet P2Y12 antagonist, with prompt and potent antiplatelet effects. Cangrelor tetrasodium directly blocks adenosine diphosphate (ADP)-induced activation and aggregation of platelets. Cangrelor tetrasodium is also a nonspecific GPR17 antagonist[1][2]. |
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| Related Catalog | |
| In Vitro | Cangrelor tetrasodium is the only potent intravenous direct and specific adenosine diphosphate (ADP) P2Y12 receptor antagonist[1]. Cangrelor tetrasodium has pKb of 8.6-9.2 for hP2Y12 receptor[3]. |
| In Vivo | Cangrelor tetrasodium (10 mg/kg) not only significantly decreases BLM-induced release of inflammatory cytokines (PF4, CD40 L and MPO), but also decreases the increment of platelets, neutrophils and platelet-neutrophil aggregates in the fibrotic lung and in the peripheral blood of BLM-treated mice[2]. |
| References |
| Boiling Point | 979ºC at 760 mmHg |
|---|---|
| Molecular Formula | C17H21Cl2F3N5Na4O12P3S2 |
| Molecular Weight | 864.286 |
| Flash Point | 545.9ºC |
| Exact Mass | 862.876099 |
| PSA | 347.26000 |
| LogP | 4.67630 |
| Vapour Pressure | 0mmHg at 25°C |
| Storage condition | -20℃ |
| Tetrasodium 5'-O-[({[dichloro(phosphonato)methyl]phosphinato}oxy)phosphinato]-N-[2-(methylsulfanyl)ethyl]-2-[(3,3,3-trifluoropropyl)sulfanyl]adenosine |
| Cangrelor tetrasodium |
| Adenosine, 5'-O-[[[(dichlorophosphonomethyl)hydroxyphosphinyl]oxy]hydroxyphosphinyl]-N-[2-(methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-, sodium salt (1:4) |
| UNII-2144G00Y7W |
| Cangrelor tetrasodium (USAN) |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: CangrelorTetrasodium
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- China
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