BAPTA tetrasodium

Modify Date: 2024-01-02 07:12:22

BAPTA tetrasodium Structure
BAPTA tetrasodium structure
Common Name BAPTA tetrasodium
CAS Number 126824-24-6 Molecular Weight 564.361
Density N/A Boiling Point 766.6ºC at 760 mmHg
Molecular Formula C22H20N2Na4O10 Melting Point N/A
MSDS USA Flash Point 417.4ºC

 Use of BAPTA tetrasodium


BAPTA tetrasodium is a selective chelator for calcium. BAPTA tetrasodium, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA tetrasodium is widely used as an intracellular buffer for investigating the effects of Ca2+ release from intracellular stores or influx via Ca2+-permeable channels in the plasma membrane. BAPTA tetrasodium can also inhibit phospholipase C activity independently of their role as Ca2+ chelators[1][2][3].

 Names

Name 1,2-Bis(2-aminophenoxy)-ethane-N,N,N,N-tetraacetic acid tetrasodium salt
Synonym More Synonyms

 BAPTA tetrasodium Biological Activity

Description BAPTA tetrasodium is a selective chelator for calcium. BAPTA tetrasodium, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA tetrasodium is widely used as an intracellular buffer for investigating the effects of Ca2+ release from intracellular stores or influx via Ca2+-permeable channels in the plasma membrane. BAPTA tetrasodium can also inhibit phospholipase C activity independently of their role as Ca2+ chelators[1][2][3].
Related Catalog
In Vitro BAPTA (0.3-30 μM; 1 h) can be used for the prevention of [Ca2+]-induced cell damage, but disturbe calcium signalling in isingle differentiated NH15-CA2 neuroblastoma and glioma hybrid cells[3]. BAPTA (0-10 mM) inhibits phospholipase C (PLC) activity in a dose-dependent manner, and is unrelated to Ca2+[2].
References

[1]. R Y Tsien, et al. New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. Biochemistry. 1980 May 27;19(11):2396-404.

[2]. Roger C Hardie, et al. Inhibition of phospholipase C activity in Drosophila photoreceptors by 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid (BAPTA) and di-bromo BAPTA. Cell Calcium. 2005 Dec;38(6):547-56.

[3]. M B Collatz, et al. Intracellular calcium chelator BAPTA protects cells against toxic calcium overload but also alters physiological calcium responses. Cell Calcium

 Chemical & Physical Properties

Boiling Point 766.6ºC at 760 mmHg
Molecular Formula C22H20N2Na4O10
Molecular Weight 564.361
Flash Point 417.4ºC
Exact Mass 564.070862
PSA 185.46000
Storage condition -20°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn
Risk Phrases R20/21/22
Safety Phrases S24/25
RIDADR NONH for all modes of transport

 Articles1

More Articles
New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures.

Biochemistry 19 , 2396, (1980)

A new family of high-affinity buffers and optical indicators for Ca2+ is rationally designed and synthesized. The parent compound is 1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA), a...

 Synonyms

1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrasodium salts (BAPTA Na)
BAPTA tetrasodium salt hydrate
BAPTA,Tetrasodium salt
BAPTA tetrasodium
Tetrasodium 2,2',2'',2'''-[1,2-ethanediylbis(oxy-2,1-phenylenenitrilo)]tetraacetate
Tetrasodium 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetate
MFCD02683087
1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrasodium salt
1,2-Bis(2-Aminophenoxy)-Ethane-N,N,N,N-Tetraacetic Acid Tetrasodium Salt
BAPTA, TETRASODIUM SALT
tetrasodium,2-[2-[2-[2-[bis(carboxylatomethyl)amino]phenoxy]ethoxy]-N-(carboxylatomethyl)anilino]acetate
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