erythrosin B

Modify Date: 2024-01-05 03:58:07

erythrosin B structure	Common Name	erythrosin B
	CAS Number	16423-68-0	Molecular Weight	879.856
	Density	0.98	Boiling Point	693.2ºC at 760 mmHg
	Molecular Formula	C₂₀H₆I₄Na₂O₅	Melting Point	>300ºC (Decomposes)
	MSDS	Chinese USA	Flash Point	373ºC
	Symbol	GHS07	Signal Word	Warning

Use of erythrosin B

Erythrosin B is an artificial dye widely used in the food and textile industries. Erythrosin B is also a novel photosensitizer which has been used to develop animal models.

Name	erythrosin B
Synonym	More Synonyms

Description	Erythrosin B is an artificial dye widely used in the food and textile industries. Erythrosin B is also a novel photosensitizer which has been used to develop animal models.
Related Catalog	Signaling Pathways >> Others >> Others Dye Reagents Research Areas >> Others
In Vitro	Only the two highest concentrations of Erythrosin B tested (50.0 and 70.0 μg/mL) are significantly different (p<0.05) from the vehicle control group when the Tail Moment and Tail Intensity, which represent the extent of DNA damage, are analyzed. Results show increased micronuclei (MNi) frequencies at six of the seven Erythrosin B concentrations (0.2 to 70.0 μg/mL) when compare to vehicle control group[1].
Cell Assay	The alkaline single-cell gel electrophoresis assay (comet assay) is performed. Briefly, 2×105 HepG2 cells are seeded in a 24-well plate for 24 h. The cells are then treated with Erythrosin B at 0.1, 0.2, 2.0, 10.0, 25.0, 50.0 or 70.0 μg/mL (final concentration) for 4 h; vehicle control (0.7% DMSO) and positive control (doxorubicin0.3 μg/mL) treatments are also performed. The HepG2 cell suspension is mixed with 37°C low-melting point agarose and transferred to normal-melting point agarose-coated slides. One hundred randomly chosen nucleoids are analyzed per treatment, and a total of three independent experiments are performed[1].
References	[1]. Chen W, et al. Establishing an experimental rat model of photodynamically-induced retinal vein occlusion using erythrosin B. Int J Ophthalmol. 2014 Apr 18;7(2):232-8. [2]. Chequer FM, et al. Genotoxic and mutagenic effects of erythrosine B, a xanthene food dye, on HepG2 cells. Food Chem Toxicol. 2012 Oct;50(10):3447-51.

Density	0.98
Boiling Point	693.2ºC at 760 mmHg
Melting Point	>300ºC (Decomposes)
Molecular Formula	C₂₀H₆I₄Na₂O₅
Molecular Weight	879.856
Flash Point	373ºC
Exact Mass	879.618896
PSA	81.65000
LogP	6.96060
Vapour Pressure	2.22E-16mmHg at 25°C
Storage condition	Store at +5°C to +30°C.
Water Solubility	100g/l

erythrosin B MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LM5950000

CHEMICAL NAME :: Fluorescein, 2',4',5',7'-tetraiodo-, disodium salt

CAS REGISTRY NUMBER :: 16423-68-0

LAST UPDATED :: 199710

DATA ITEMS CITED :: 31

MOLECULAR FORMULA :: C20-H6-I4-O5.2Na

MOLECULAR WEIGHT :: 879.84

WISWESSER LINE NOTATION :: T C666 BO EVJ DI FI IR BVQ& LI MQ NI &-NA- 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1840 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1895 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1264 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 370 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - gerbil

DOSE/DURATION :: 1930 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 90 gm/kg/90D-C

TOXIC EFFECTS :: Gastrointestinal - other changes Endocrine - changes in thyroid weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - pig

DOSE/DURATION :: 147 gm/kg/14W-I

TOXIC EFFECTS :: Endocrine - changes in thyroid weight Blood - changes in leukocyte (WBC) count

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1798 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Endocrine - thyroid tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 482 gm/kg

SEX/DURATION :: multigeneration

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 1100 mg/L

REFERENCE :: GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M4011 No. of Facilities: 904 (estimated) No. of Industries: 5 No. of Occupations: 11 No. of Employees: 8221 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M4011 No. of Facilities: 2991 (estimated) No. of Industries: 17 No. of Occupations: 39 No. of Employees: 67011 (estimated) No. of Female Employees: 25006 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H413
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22
Safety Phrases	36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	LM5950000
HS Code	32129000

Gold(I) complexes of 9-deazahypoxanthine as selective antitumor and anti-inflammatory agents.

PLoS ONE 9(10) , e109901, (2014)

The gold(I) mixed-ligand complexes involving O-substituted derivatives of 9-deazahypoxanthine (HLn) and triphenylphosphine (PPh3) with the general formula [Au(Ln)(PPh3)] (1-5) were prepared and thorou...

Evaluation of potential genotoxicity of five food dyes using the somatic mutation and recombination test.

Chemosphere 88(8) , 974-9, (2012)

In this study, different concentrations of five food dyes (amaranth, patent blue, carminic acid, indigotine and erythrosine) have been evaluated for genotoxicity in the Somatic Mutation and Recombinat...

Hypoxia enhances proliferation and stemness of human adipose-derived mesenchymal stem cells.

Cytotechnology 67 , 1073-84, (2015)

The aim of the study was to obtain the highest number of multipotent adipose-derived mesenchymal stem cells (ADMSCs) by using culture conditions which favour cell expansion without loss of mesenchymal...

1427red

Erythrosin B,high purity,biological stain

Erythrosin

Tetraiodofluorescein sodium salt

Erythrosine Sodium (close form)

Disodium 2-(2,4,5,7-tetraiodo-6-oxido-3-oxo-3H-xanthen-9-yl)benzoate

Benzoic acid, 2-(6-hydroxy-2,4,5,7-tetraiodo-3-oxo-3H-xanthen-9-yl)-, sodium salt (1:2)

2',4',5',7'-Tetraiodofluorescein disodium salt

Erythrosin extra bluish

IODOEOSIN

FD & C Red 3

Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3',6'-dihydroxy-2',4',5',7'-tetraiodo-, sodium salt (1:2)

EINECS 240-474-8

3',6'-Dihydroxy-2',4',5',7'-tetraiodospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one Disodium Salt

FDC red no. 3

Disodium 2',4',5',7'-tetraiodo-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-3',6'-diolate

Sodium 2',4',5',7'-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-bis(olate)

1671red

Food Red No. 3

c.i.773

Japan Red 3

EOSIN J

FD and C Red No. 3

Synerid

MFCD00144257

fdcred3

CRED3

ebs

Ceplac

Erythrosin B,certified

lb-rot1

Erythrosin B

Acid Red 51

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: erythrosin B
Price: ￥148.0/25g
Purity: 85.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Erythrosine sodium (close form)
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Erythrosin B
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: ERYTHROSIN B
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: ERYTHROSIN B
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: $66/10mM*1mLinWater

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erythrosin B

Use of erythrosin B

Names

erythrosin B Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

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Synonyms