KPT-8602
Modify Date: 2024-01-09 18:48:08
KPT-8602 structure
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Common Name | KPT-8602 | ||
|---|---|---|---|---|
| CAS Number | 1642300-52-4 | Molecular Weight | 428.291 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 574.4±60.0 °C at 760 mmHg | |
| Molecular Formula | C17H10F6N6O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 301.2±32.9 °C | |
Use of KPT-8602KPT-8602 is a second-generation exportin-1 inhibitor, shows similar in vitro potency compared with KPT-330.In vitro: KPT-8602 induces caspase-dependent apoptosis in a panel of leukemic cell lines in vitro. Using CRISPR/Cas9 genome editing we demonstrats the specificity of KPT-8602 for cysteine 528 in the cargo-binding groove of XPO1 and validats the drug target interaction. [1]In vivo: KPT-8602 shows potent anti-leukemia activity in a mouse ALL model as well as in patient-derived T- and B-ALL xenograft models without affecting normal hematopoiesis.[1] |
| Name | eltanexor |
|---|---|
| Synonym | More Synonyms |
| Description | KPT-8602 is a second-generation exportin-1 inhibitor, shows similar in vitro potency compared with KPT-330.In vitro: KPT-8602 induces caspase-dependent apoptosis in a panel of leukemic cell lines in vitro. Using CRISPR/Cas9 genome editing we demonstrats the specificity of KPT-8602 for cysteine 528 in the cargo-binding groove of XPO1 and validats the drug target interaction. [1]In vivo: KPT-8602 shows potent anti-leukemia activity in a mouse ALL model as well as in patient-derived T- and B-ALL xenograft models without affecting normal hematopoiesis.[1] |
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| Related Catalog | |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 574.4±60.0 °C at 760 mmHg |
| Molecular Formula | C17H10F6N6O |
| Molecular Weight | 428.291 |
| Flash Point | 301.2±32.9 °C |
| Exact Mass | 428.082031 |
| LogP | 2.83 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.594 |
| Storage condition | -20℃ |
| eltanexor |
| 5-Pyrimidineacetamide, α-[[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]methylene]-, (αE)- |
| (2E)-3-{3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-2-(5-pyrimidinyl)acrylamide |
| KPT-8602 |