PDK1-IN-RS2

Modify Date: 2024-01-15 11:22:33

PDK1-IN-RS2 structure	Common Name	PDK1-IN-RS2
	CAS Number	1643958-89-7	Molecular Weight	380.89
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅H₉ClN₂O₂S₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PDK1-IN-RS2

PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor with a Kd of 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 by PDK1[1].

Name	PDK1-IN-RS2

Description	PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor with a Kd of 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 by PDK1[1].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> PDK-1 Research Areas >> Cancer
Target	Kd: 9 μM (PDK1)[1]
In Vitro	PDK1-IN-RS2 stimulates the catalytic activity of PDK1 toward a peptide substrate by sixfold. The sulfonyl group of PDK1-IN-RS2 interacts with Arg131 through a salt bridge, because the sulfonamide is likely ionized under the crystallization conditions[1].
References	[1]. Rettenmaier TJ, et al. A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18590-5.

Molecular Formula	C₁₅H₉ClN₂O₂S₃
Molecular Weight	380.89

DC Chemicals Limited
China
Product Name: PDK1-IN-RS2
Price:
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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