hDHODH-IN-2

Modify Date: 2024-01-20 07:58:57

hDHODH-IN-2 Structure
hDHODH-IN-2 structure
Common Name hDHODH-IN-2
CAS Number 183946-00-1 Molecular Weight 304.34
Density N/A Boiling Point N/A
Molecular Formula C19H16N2O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of hDHODH-IN-2


hDHODH-IN-2 is an analogue of the active metabolite of Leflunomide. hDHODH-IN-2 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor. hDHODH-IN-1 has anti-inflammatory activity[1][2].

 Names

Name hDHODH-IN-2

 hDHODH-IN-2 Biological Activity

Description hDHODH-IN-2 is an analogue of the active metabolite of Leflunomide. hDHODH-IN-2 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor. hDHODH-IN-1 has anti-inflammatory activity[1][2].
Related Catalog
In Vitro hDHODH-IN-2 (Compound 42) inhibits rat and mouse DHODH with log(1/IC50) values of 5.83 and 5.80, respectively in self-organizing molecular field analysis (SOMFA)[1].
References

[1]. Li SL, et al. 3D-QSAR studies on a series of dihydroorotate dehydrogenase inhibitors: analogues of the active metabolite of leflunomide. Int J Mol Sci. 2011;12(5):2982-93.

[2]. Shih KC, et al. Development of a human dihydroorotate dehydrogenase (hDHODH) pharma-similarity index approach with scaffold-hopping strategy for the design of novel potential inhibitors. PLoS One. 2014 Feb 4;9(2):e87960.

 Chemical & Physical Properties

Molecular Formula C19H16N2O2
Molecular Weight 304.34
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