DKM 3-42

Modify Date: 2024-01-04 11:24:01

DKM 3-42 Structure
DKM 3-42 structure
Common Name DKM 3-42
CAS Number 164925-73-9 Molecular Weight 207.317
Density N/A Boiling Point N/A
Molecular Formula C13H21NO Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DKM 3-42


DKM 3-42 is a selective, covalent, in vivo-active ALDH3A1 inhibitor with IC50 of 50 uM against purified human ALDH3A1, targets ALDH3A1 catalytic cysteine, impairs both in situ and in vivo lung cancer pathogenicity; impairs A549 serum-survival in a dose-responsive manner, significantly attenuates tumor growth in vivo in A549 tumor xenografts in mice with dose of DKM 3-42 (50mg/kg ip) once per day.

 Names

Name DKM 3-42

 DKM 3-42 Biological Activity

Description DKM 3-42 is a selective, covalent, in vivo-active ALDH3A1 inhibitor with IC50 of 50 uM against purified human ALDH3A1, targets ALDH3A1 catalytic cysteine, impairs both in situ and in vivo lung cancer pathogenicity; impairs A549 serum-survival in a dose-responsive manner, significantly attenuates tumor growth in vivo in A549 tumor xenografts in mice with dose of DKM 3-42 (50mg/kg ip) once per day.
References References 1. Counihan JL, et al. ACS Chem Biol. 2018 Jul 13. doi: 10.1021/acschembio.8b00381. View Related Products by Target Aldehyde Dehydrogenase (ALDH)

 Chemical & Physical Properties

Molecular Formula C13H21NO
Molecular Weight 207.317