Anhydrotetracyclin

Modify Date: 2026-07-27 13:54:21

Anhydrotetracyclin structure	Common Name	Anhydrotetracyclin
	CAS Number	1665-56-1	Molecular Weight	426.41900
	Density	1.6 g/cm3	Boiling Point	618.6ºC at 760 mmHg
	Molecular Formula	C₂₂H₂₂N₂O₇	Melting Point	N/A
	MSDS	N/A	Flash Point	327.9ºC

Use of Anhydrotetracyclin

Anhydrotetracycline shows dose-dependent and potent inhibition of tetracycline destructases in vitro[1].

Summary: Dehydrated Difieroxycycline, also known as Anhydrotetracyclin, has a CAS number of 1665-56-1, with a molecular formula of C22H22N2O7 and a molecular weight of 426.41900. For research-use only, not for medical or clinical usage.

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	(4S,4aS,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-6-methyl-3,12-dioxo-4a,5-dihydro-4H-tetracene-2-carboxamide
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Anhydrotetracycline shows dose-dependent and potent inhibition of tetracycline destructases in vitro[1].
Related Catalog	Research Areas >> Infection
Target	Tetracycline inactivating enzyme[1]
In Vitro	体外实验表明，Anhydrotetracycline (0.1 μM-10 mM) 对四环素破坏酶具有剂量依赖性和强抑制作用[1]。
References	[1]. Markley JL, et al. Semisynthetic Analogues of Anhydrotetracycline as Inhibitors of Tetracycline Destructase Enzymes. ACS Infect Dis. 2019 Apr 12;5(4):618-633.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.6 g/cm3
Boiling Point	618.6ºC at 760 mmHg
Molecular Formula	C₂₂H₂₂N₂O₇
Molecular Weight	426.41900
Flash Point	327.9ºC
Exact Mass	426.14300
PSA	161.39000
LogP	1.15610
Vapour Pressure	3.66E-16mmHg at 25°C
Index of Refraction	1.76
InChIKey	KTTKGQINVKPHLY-DOCRCCHOSA-N
SMILES	Cc1c2c(c(O)c3c(O)cccc13)C(=O)C1(O)C(O)=C(C(N)=O)C(=O)C(N(C)C)C1C2

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QI9277520

CHEMICAL NAME :: 2-Naphthacenecarboxamide, 1,4,4a,5,12,12a-hexahydro-4-(dimethylamino)-1,12-diox o-6-methyl- 3,10,11,12a-tetrahydroxy-, (4S-(4-alpha,4a-alpha,12a-alpha))-

CAS REGISTRY NUMBER :: 1665-56-1

LAST UPDATED :: 199009

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C22-H22-N2-O7

MOLECULAR WEIGHT :: 426.46

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 134 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 34 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Ascites tumor

DOSE/DURATION :: 20 mg/L

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 30,403,1974

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Hazard Codes	T

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 0
DownStream 1
CAS#:60-54-8 Tetracycline

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Transactivation of Reverse transactivator Tet repressor-S3 SL439, FG442, SL444 and FA...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1219003

Name: Inhibition of Dicer mediated biotinylated pre-miRNA-21 (unknown origin) maturation at...
Source: ChEMBL
Target: microRNA 21
External Id: CHEMBL4364428

Total 2, Current Page 1 of 1

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

5a,6-Anhydrotetracycline

Anhydrotetracyclin

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the boiling point of (4S,4aS,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-6-methyl-3,12-dioxo-4a,5-dihydro-4H-tetracene-2-carboxamide?

A: Boiling point of (4S,4aS,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-6-methyl-3,12-dioxo-4a,5-dihydro-4H-tetracene-2-carboxamide is 618.6ºC at 760 mmHg.

Q: What is the InChIKey of (4S,4aS,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-6-methyl-3,12-dioxo-4a,5-dihydro-4H-tetracene-2-carboxamide?

A: InChIKey of (4S,4aS,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-6-methyl-3,12-dioxo-4a,5-dihydro-4H-tetracene-2-carboxamide is KTTKGQINVKPHLY-DOCRCCHOSA-N.

Q: What are the downstream products of (4S,4aS,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-6-methyl-3,12-dioxo-4a,5-dihydro-4H-tetracene-2-carboxamide?

A: Related downstream products(CAS) of (4S,4aS,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-6-methyl-3,12-dioxo-4a,5-dihydro-4H-tetracene-2-carboxamide: 60-54-8.

Q: What is the LogP of (4S,4aS,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-6-methyl-3,12-dioxo-4a,5-dihydro-4H-tetracene-2-carboxamide?

A: LogP of (4S,4aS,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-6-methyl-3,12-dioxo-4a,5-dihydro-4H-tetracene-2-carboxamide is 1.15610.

Q: What is the English name of (4S,4aS,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-6-methyl-3,12-dioxo-4a,5-dihydro-4H-tetracene-2-carboxamide?

A: The English name of (4S,4aS,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-6-methyl-3,12-dioxo-4a,5-dihydro-4H-tetracene-2-carboxamide is (4S,4aS,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-6-methyl-3,12-dioxo-4a,5-dihydro-4H-tetracene-2-carboxamide.

Q: What English synonyms does (4S,4aS,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-6-methyl-3,12-dioxo-4a,5-dihydro-4H-tetracene-2-carboxamide have?

A: English synonyms of (4S,4aS,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-6-methyl-3,12-dioxo-4a,5-dihydro-4H-tetracene-2-carboxamide: 5a,6-Anhydrotetracycline, Anhydrotetracyclin.

Q: What is the SMILES notation of (4S,4aS,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-6-methyl-3,12-dioxo-4a,5-dihydro-4H-tetracene-2-carboxamide?

A: SMILES notation of (4S,4aS,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-6-methyl-3,12-dioxo-4a,5-dihydro-4H-tetracene-2-carboxamide is Cc1c2c(c(O)c3c(O)cccc13)C(=O)C1(O)C(O)=C(C(N)=O)C(=O)C(N(C)C)C1C2.

Q: What is the polar surface area (PSA) of (4S,4aS,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-6-methyl-3,12-dioxo-4a,5-dihydro-4H-tetracene-2-carboxamide?

A: Polar surface area (PSA) of (4S,4aS,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-6-methyl-3,12-dioxo-4a,5-dihydro-4H-tetracene-2-carboxamide is 161.39000.

Q: What is the CAS number of (4S,4aS,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-6-methyl-3,12-dioxo-4a,5-dihydro-4H-tetracene-2-carboxamide?

A: CAS number of (4S,4aS,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-6-methyl-3,12-dioxo-4a,5-dihydro-4H-tetracene-2-carboxamide is 1665-56-1.

Q: What is the molecular formula of (4S,4aS,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-6-methyl-3,12-dioxo-4a,5-dihydro-4H-tetracene-2-carboxamide?

A: Molecular formula of (4S,4aS,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-6-methyl-3,12-dioxo-4a,5-dihydro-4H-tetracene-2-carboxamide is C22H22N2O7.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Anhydrotetracycline
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (2Z,4S,4aS,12aS)-2-(amino-hydroxy-methylidene)-4-dimethylamino-10,11,1 2a-trihydroxy-6-methyl-4a,5-dihydro-4H-tetracene-1,3,12-trione
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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