3-Hydroxy Carbofuran

Modify Date: 2024-01-06 23:54:27

3-Hydroxy Carbofuran Structure
3-Hydroxy Carbofuran structure
Common Name 3-Hydroxy Carbofuran
CAS Number 16655-82-6 Molecular Weight 237.25
Density 1.2±0.1 g/cm3 Boiling Point 344.7±42.0 °C at 760 mmHg
Molecular Formula C12H15NO4 Melting Point 140-148ºC
MSDS Chinese USA Flash Point 162.2±27.9 °C
Symbol GHS06
GHS06
Signal Word Danger

 Use of 3-Hydroxy Carbofuran


3-Hydroxycarbofuran, a major metabolite of Carbofuran, is a reversible acetylcholinesterase (AChE) inhibitor[1].

 Names

Name (3-hydroxy-2,2-dimethyl-3H-1-benzofuran-7-yl) N-methylcarbamate
Synonym More Synonyms

 3-Hydroxy Carbofuran Biological Activity

Description 3-Hydroxycarbofuran, a major metabolite of Carbofuran, is a reversible acetylcholinesterase (AChE) inhibitor[1].
Related Catalog
References

[1]. Duraisamy Kempuraj, et al. Carbofuran pesticide toxicity to the eye. Exp Eye Res. 2023 Feb;227:109355.  

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 344.7±42.0 °C at 760 mmHg
Melting Point 140-148ºC
Molecular Formula C12H15NO4
Molecular Weight 237.25
Flash Point 162.2±27.9 °C
Exact Mass 237.100113
PSA 67.79000
LogP 0.21
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.553
Storage condition APPROX 4°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
FB9500000
CHEMICAL NAME :
Carbamic acid, methyl-, 2,3-dihydro-2,2-dimethyl-3-hydroxy-7-benzofuranyl ester
CAS REGISTRY NUMBER :
16655-82-6
BEILSTEIN REFERENCE NO. :
1383873
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C12-H15-N-O4
MOLECULAR WEIGHT :
237.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
100 mg/L
REFERENCE :
TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 18(1),17,1984

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H300
Precautionary Statements P264-P301 + P310
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes T+,Xi,F
Risk Phrases R28
Safety Phrases S28
RIDADR UN 2757
RTECS FB9500000
Packaging Group II
Hazard Class 6.1(a)
HS Code 2932999099

 Synthetic Route

~34%

3-Hydroxy Carbofuran Structure

3-Hydroxy Carbofuran

CAS#:16655-82-6

Literature: Keserue, Gyoergy M.; Balogh, Gyoergy; Czudor, Iren; Karancsi, Tamas; Feher, Andras; Bertok, Bela Journal of Agricultural and Food Chemistry, 1999 , vol. 47, # 2 p. 762 - 769

~%

3-Hydroxy Carbofuran Structure

3-Hydroxy Carbofuran

CAS#:16655-82-6

Literature: Journal of Agricultural and Food Chemistry, , vol. 47, # 2 p. 762 - 769

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles18

More Articles
Determination of pesticides in soy-based infant formula using liquid chromatography with electrospray ionization tandem mass spectrometry.

J. AOAC Int. 89(1) , 214-24, (2006)

A sensitive method using liquid chromatography with electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) was developed and validated to quantify and confirm 13 pesticides, including aldicar...

Metabolism of carbofuran by Aspergillus niger and Fusarium graminearum.

J. Environ. Sci. Health B 33(3) , 253-66, (1998)

Metabolism of carbofuran in pure liquid cultures of A. niger and F. graminearum was investigated. Carbofuran and its metabolites were analyzed by HPLC and TLC. The average recoveries of carbofuran, 3-...

Surprising hair analysis results following acute carbofuran intoxication.

Forensic Sci. Int. 212(1-3) , e10-4, (2011)

We present two non fatal cases of intoxication with carbofuran (CBF) documented by hair analysis. Carbofuran and 3-hydroxycarbofuran (OHCBF, its main metabolite) hair concentrations were determined us...

 Synonyms

methylcarbamic acid 2,2-dimethyl-3-hydroxy-2,3-dihydrobenzofuran-7-yl ester
2,3-dihydro-3-hydroxy-2,2-dimethylbenzofuran-7-yl methylcarbamate
Carbamic acid,methyl-,2,3-dihydro-2,2-dimethyl-3-hydroxy-7-benzofuranyl ester
Methylcarbamic acid 2,3-dihydro-2,2-dimethyl-3-hydroxy-7-benzofuranyl ester
Carbofuran-3-hydroxy solution
T56 BOT&J C1 C1 DQ IOVM1
MFCD00143168
3,7-Benzofurandiol, 2,3-dihydro-2,2-dimethyl-, 7-(methylcarbamate)
Carbofuran-3-hydroxy
2,3-dihydro-2,2-dimethyl-3-hydroxybenzofuran-7-yl methylcarbamate
3-Hydroxy-2,2-dimethyl-2,3-dihydro-1-benzofuran-7-yl methylcarbamate
3-Hydroxycarbofuran
3-Hydroxy-2,2-dimethyl-2,3-dihydro-1-benzofur-7-yl-methylcarbamat
3-hydroxy-2,3-dihydro-2,2-dimethylbenzofuran-7-yl methylcarbamate
2,3-Dihydro-2,2-dimethyl-3,7-benzofurandiol 7-(methylcarbamate)
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