KAR-5585
Modify Date: 2025-08-24 19:27:26
KAR-5585 structure
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Common Name | KAR-5585 | ||
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| CAS Number | 1673571-51-1 | Molecular Weight | 590.04 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H31ClF3N5O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of KAR-5585Rodatristat ethyl (KAR5585) is an orally active tryptophan hydroxylase 1 (TPH1) inhibitor with nanomolar in vitro potency. Rodatristat ethyl reduces the level of 5-HT and significantly reduces pulmonary arterial hypertension (PAH)[1][2]. |
| Name | Rodatristat ethyl |
|---|
| Description | Rodatristat ethyl (KAR5585) is an orally active tryptophan hydroxylase 1 (TPH1) inhibitor with nanomolar in vitro potency. Rodatristat ethyl reduces the level of 5-HT and significantly reduces pulmonary arterial hypertension (PAH)[1][2]. |
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| Related Catalog | |
| In Vivo | Rodatristat ethyl (100 or 200 mg/kg; oral administration; once daily; for 28 days; male Sprague-Dawley rats) treatment decreases erum, gut and lung 5-HT levels in a dose-dependent manner and significantly reduces pulmonary arterial pressure, and pulmonary vessel wall thickness and occlusion in male rats with monocrotaline (MCT)[1]. Animal Model: Male Sprague-Dawley rats (175-200 g)[1] Dosage: 100 mg/kg or 200 mg/kg Administration: Oral administration; once daily; for 28 days Result: Decreased serum, gut and lung 5-HT levels in a dose-dependent manner and significantly reduced pulmonary arterial pressure, and pulmonary vessel wall thickness and occlusion in male rats. |
| References |
| Molecular Formula | C29H31ClF3N5O3 |
|---|---|
| Molecular Weight | 590.04 |
| InChIKey | TZSZZENYCISATO-WIOPSUGQSA-N |
| SMILES | CCOC(=O)C1CC2(CCN(c3cc(OC(c4ccc(Cl)cc4-c4ccccc4)C(F)(F)F)nc(N)n3)CC2)CN1 |