Venadaparib hydrochloride
Modify Date: 2024-01-07 11:31:22
Venadaparib hydrochloride structure
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Common Name | Venadaparib hydrochloride | ||
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| CAS Number | 1681020-60-9 | Molecular Weight | 442.91 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H24ClFN4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Venadaparib hydrochlorideVenadaparib (IDX-1197) hydrochloride is a potent and selective PARP inhibitor with anticancer activities. Venadaparib hydrochloride can be used for solid tumors research[1][2]. |
| Name | Venadaparib hydrochloride |
|---|
| Description | Venadaparib (IDX-1197) hydrochloride is a potent and selective PARP inhibitor with anticancer activities. Venadaparib hydrochloride can be used for solid tumors research[1][2]. |
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| Related Catalog | |
| Target |
PARP1:1.4 nM (IC50) PARP2:1 nM (IC50) |
| In Vitro | Venadaparib (example 143; 6-10 days) shows potent growth inhibition of MDA-MB-436 cells and Capan-1 pancreatic cancer cells with IC50 values of ≤5nM and 50nM [2]. |
| In Vivo | In the germline BRCA1-mutated ovarian cancer PDX model, oral administration of Venadaparib (IDX-1197) exhibits significant PAR inhibition (>90%) in tumor tissues until 24 hr post dose. Venadaparib also dose-dependently led to potent tumor growth inhibition compared to Olaparib treatment group[1]. |
| References |
| Molecular Formula | C23H24ClFN4O2 |
|---|---|
| Molecular Weight | 442.91 |