Agitoxin 2

Modify Date: 2025-08-27 11:02:49

Use of Agitoxin 2

Agitoxin-2 is a K+ channel inhibitor, with IC50 values of 201 pM and 144 pM for mKV1.3 and mKV1.1, respectively)[1][2].

Name	Agitoxin-2

Description	Agitoxin-2 is a K+ channel inhibitor, with IC50 values of 201 pM and 144 pM for mKV1.3 and mKV1.1, respectively)[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
References	[1]. M L Garcia, et al. Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus quinquestriatus var. hebraeus venom. Biochemistry. 1994 Jun 7;33(22):6834-9. [2]. Raveendra Anangi, et al. Recombinant expression of margatoxin and agitoxin-2 in Pichia pastoris: an efficient method for production of KV1.3 channel blockers.

Description

Agitoxin-2 is a K+ channel inhibitor, with IC50 values of 201 pM and 144 pM for mKV1.3 and mKV1.1, respectively)[1][2].

Related Catalog

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

References

Molecular Formula	C₁₆₉H₂₇₈N₅₄O₄₈S₈
Molecular Weight	4090.87
InChIKey	MNSSWZUIQUJZTG-UHFFFAOYSA-N
SMILES	CCC(C)C1NC(=O)C2CSSCC3NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(N)=O)NC(=O)C(CCSC)NC(=O)C(CSSCC(NC(=O)C(CO)NC(=O)C(NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C4CCCN4C(=O)C(NC(=O)CN)C(C)C)C(C)CC)C(C)C)C(=O)NC(C(C)O)C(=O)NCC(=O)NC(CO)C(=O)N4CCCC4C(=O)NC(CCC(N)=O)C(=O)N2)NC(=O)C(CCCCN)NC(=O)CNC(=O)C(Cc2ccccc2)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCSC)NC(=O)CNC(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CCCCN)NC(=O)C(CSSCC(C(=O)NC(C(=O)N2CCCC2C(=O)NC(CCCCN)C(=O)O)C(C)O)NC(=O)C(Cc2c[nH]cn2)NC3=O)NC(=O)C2CCCN2C(=O)C(CCCCN)NC1=O

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