Cyasterone

Modify Date: 2024-01-05 12:39:46

Cyasterone structure	Common Name	Cyasterone
	CAS Number	17086-76-9	Molecular Weight	520.655
	Density	1.3±0.1 g/cm3	Boiling Point	742.8±60.0 °C at 760 mmHg
	Molecular Formula	C₂₉H₄₄O₈	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	242.0±26.4 °C

Use of Cyasterone

Cyasterone, a natural EGFR inhibitor, mainly isolated from Ajuga decumbens Thunb (Labiatae).Cyasterone manifests anti-proliferation effect by induced apoptosis and cell cycle arrests. Cyasterone may serves as a clinical therapeutic anti-tumor agent against human tumors[1].

Name	cyasterone
Synonym	More Synonyms

Description	Cyasterone, a natural EGFR inhibitor, mainly isolated from Ajuga decumbens Thunb (Labiatae).Cyasterone manifests anti-proliferation effect by induced apoptosis and cell cycle arrests. Cyasterone may serves as a clinical therapeutic anti-tumor agent against human tumors[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
In Vitro	Cyasterone (0-100μM; 24hours) inhibits cell growth in a concentration-and time-dependent manner, IC50 values are 38.50 mg/mL, 32.96 mg/mL in A549 and MGC823 cells ,respectively[1]. Cell Viability Assay[1] Cell Line: A549, HCT116, MGC823 cells Concentration: 0-100 μM Incubation Time: 24 hours Result: Inhibited the growth of 3 human cancer lines A549, HCT116, MGC823 cells.
References	[1]. Lu X, et al. Anti-proliferation effects, efficacy of cyasterone in vitro and in vivo and its mechanism. Biomed Pharmacother. 2016 Dec;84:330-339.

Density	1.3±0.1 g/cm3
Boiling Point	742.8±60.0 °C at 760 mmHg
Molecular Formula	C₂₉H₄₄O₈
Molecular Weight	520.655
Flash Point	242.0±26.4 °C
Exact Mass	520.303589
PSA	144.52000
LogP	-0.25
Vapour Pressure	0.0±5.6 mmHg at 25°C
Index of Refraction	1.600

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WJ2510000

CHEMICAL NAME :: 5-beta-Stigmast-7-en-26-oic acid, 2-beta,3-beta,14,20,22,28-hexahydroxy-6-oxo-, gamma- lactone, (22R,24S,25S,28R)-

CAS REGISTRY NUMBER :: 17086-76-9

LAST UPDATED :: 198909

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C29-H44-O8

MOLECULAR WEIGHT :: 520.73

WISWESSER LINE NOTATION :: L E5 B666 LV JUTJ IQ OQ PQ FXQ1&YQ1YYQ1&Y1&- CT4OVTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TEST SYSTEM :: Insect - Drosophila melanogaster

DOSE/DURATION :: 300 umol/L

REFERENCE :: NNBYA7 Nature (London), New Biology. (Basingstoke, Hants., UK) V.229-246, 1971-73. For publisher information, see NATUAS. Volume(issue)/page/year: 230,222,1971

Safety Phrases	24/25
RIDADR	NONH for all modes of transport
RTECS	WJ2510000

(2β,3β,5β,22R,24S,25S,28R)-2,3,14,20,22-Pentahydroxy-26,28-epoxystigmast-7-ene-6,26-dione

(2β,3β,5β,23R,24ξ,25S,28R)-2,3,14,20,23-Pentahydroxy-26,28-epoxystigmast-7-ene-6,26-dione

Stigmast-7-ene-6,26-dione, 26,28-epoxy-2,3,14,20,23-pentahydroxy-, (2β,3β,5β,23R,24ξ,25S,28R)-

cyasteron

Stigmast-7-ene-6,26-dione, 26,28-epoxy-2,3,14,20,22-pentahydroxy-, (2β,3β,5β,22R,24S,25S,28R)-

Cyasterone

BioBioPha
China
Product Name: Cyasterone
Price: ￥Inquiry/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Cyasterone
Price: ￥748.0/10mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Cyasterone
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Cyasterone

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