杯苋甾酮

• 常用名: 杯苋甾酮
• 英文名: Cyasterone
• CAS号: 17086-76-9
• 分子量: 520.655
• 密度: 1.3±0.1 g/cm3
• 沸点: 742.8±60.0 °C at 760 mmHg
• 分子式: C₂₉H₄₄O₈
• 熔点: N/A
• 闪点: 242.0±26.4 °C

杯苋甾酮用途

Cyasterone,一种天然的 EGFR 抑制剂,主要分离自 Ajuga decumbens Thunb (Labiatae)。Cyasterone 通过诱导细胞凋亡 (apoptosis) 和细胞周期阻滞表现出抗增殖作用。 Cyasterone 可作为抗人类肿瘤的临床治疗性药物。

杯苋甾酮名称

• 中文名: 杯苋甾酮
• 英文名: cyasterone
• 中文别名: 杯觅甾酮

杯苋甾酮生物活性

• 描述: Cyasterone,一种天然的 EGFR 抑制剂,主要分离自 Ajuga decumbens Thunb (Labiatae)。Cyasterone 通过诱导细胞凋亡 (apoptosis) 和细胞周期阻滞表现出抗增殖作用。 Cyasterone 可作为抗人类肿瘤的临床治疗性药物。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> JAK/STAT信号通路 >> EGFR
  信号通路 >> 蛋白酪氨酸激酶 >> EGFR
• 体外研究: 半胱氨酸(0-100μM; 24小时)以浓度和时间依赖性方式抑制细胞生长,A549和MGC823细胞中IC50值分别为38.50 mg/mL,32.96 mg/mL [1]。细胞活力测定[1]细胞系：A549,HCT116,MGC823细胞浓度：0-100μM培养时间：24小时结果：抑制3种人癌细胞系A549,HCT116,MGC823细胞的生长。
• 参考文献:

  [1]. Lu X, et al. Anti-proliferation effects, efficacy of cyasterone in vitro and in vivo and its mechanism. Biomed Pharmacother. 2016 Dec;84:330-339.

杯苋甾酮物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 742.8±60.0 °C at 760 mmHg
• 分子式: C₂₉H₄₄O₈
• 分子量: 520.655
• 闪点: 242.0±26.4 °C
• 精确质量: 520.303589
• PSA: 144.52000
• LogP: -0.25
• InChIKey: NEFYSBQJYCICOG-YSEUJXISSA-N
• SMILES: CC1OC(=O)C(C)C1CC(O)C(C)(O)C1CCC2(O)C3=CC(=O)C4CC(O)C(O)CC4(C)C3CCC12C
• 蒸汽压: 0.0±5.6 mmHg at 25°C
• 折射率: 1.600

杯苋甾酮毒性和生态

杯苋甾酮安全信息

• 安全声明 (欧洲): 24/25
• 危险品运输编码: NONH for all modes of transport
• RTECS号: WJ2510000

杯苋甾酮靶点实验

查看更多实验

实验名称：Inhibition of human ABCB1 expressed in mouse L5178 cells assessed as 50% inhibition o... 来源：ChEMBL 靶标：ATP-dependent translocase ABCB1 External Id：CHEMBL2091094

实验名称：Inhibition of 12-O-tetradecanoylphorbol-13-acetate induced EBV-early antigen activati... 来源：ChEMBL 靶标：N/A External Id：CHEMBL979678

实验名称：Binding affinity to ecdysone receptor ligand binding domain in Drosophila melanogaste... 来源：ChEMBL 靶标：Ecdysone receptor External Id：CHEMBL1051107

实验名称：Inhibition of 12-O-tetradecanoylphorbol-13-acetate induced EBV-early antigen activati... 来源：ChEMBL 靶标：N/A External Id：CHEMBL979677

实验名称：Inhibition of human ABCB1 expressed in mouse L5178 cells assessed as 75% inhibition o... 来源：ChEMBL 靶标：ATP-dependent translocase ABCB1 External Id：CHEMBL2091097

实验名称：Cytotoxicity against human Raji cells assessed as cell viability at 10 molar ratio af... 来源：ChEMBL 靶标：Raji External Id：CHEMBL979684

实验名称：Cytotoxicity against human Raji cells assessed as cell viability at 100 molar ratio a... 来源：ChEMBL 靶标：Raji External Id：CHEMBL979683

实验名称：Inhibition of DMBA-induced/TPA-promoted carcinogenesis in mouse assessed as number of... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL980478

实验名称：Inhibition of DMBA-induced/TPA-promoted carcinogenesis in mouse assessed as number of... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL979685

实验名称：Inhibition of 12-O-tetradecanoylphorbol-13-acetate induced EBV-early antigen activati... 来源：ChEMBL 靶标：N/A External Id：CHEMBL979680

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杯苋甾酮英文别名

• (2β,3β,5β,22R,24S,25S,28R)-2,3,14,20,22-Pentahydroxy-26,28-epoxystigmast-7-ene-6,26-dione
• (2β,3β,5β,23R,24ξ,25S,28R)-2,3,14,20,23-Pentahydroxy-26,28-epoxystigmast-7-ene-6,26-dione
• cyasteron
• Cyasterone