12-epi-TadalafilTadalafil

Modify Date: 2025-08-20 18:30:43

12-epi-TadalafilTadalafil structure	Common Name	12-epi-TadalafilTadalafil
	CAS Number	171596-27-3	Molecular Weight	389.40
	Density	1.51±0.1 g/cm3 (20 ºC 760 Torr)	Boiling Point	N/A
	Molecular Formula	C₂₂H₁₉N₃O₄	Melting Point	295-296 ºC
	MSDS	N/A	Flash Point	N/A

Use of 12-epi-TadalafilTadalafil

cis-Tadalafil is a PDE5 inhibitor (IC50: 0.09 μM). cis-Tadalafil can be used for research of cardiovascular diseases[1].

Name	(6R,12aS)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Synonym	More Synonyms

Description	cis-Tadalafil is a PDE5 inhibitor (IC50: 0.09 μM). cis-Tadalafil can be used for research of cardiovascular diseases[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Target	PDE5:0.09 μM (IC50)
In Vitro	cis-Tadalafil (Compound 12b) 抑制 PDE5，IC50 为 0.09 μM[1]。
References	[1]. Daugan A, et al. The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues. J Med Chem. 2003 Oct 9;46(21):4533-42.

Density	1.51±0.1 g/cm3 (20 ºC 760 Torr)
Melting Point	295-296 ºC
Molecular Formula	C₂₂H₁₉N₃O₄
Molecular Weight	389.40
Exact Mass	389.13800
PSA	74.87000
LogP	2.08710
Water Solubility	Insuluble (8.6E-3 g/L) (25 ºC)

Cialis

CAS#:171596-29-5

~95%

12-epi-Tadalafi...

CAS#:171596-27-3

Literature: Tetrahedron Asymmetry, , vol. 19, # 4 p. 435 - 442

methylamine

CAS#:74-89-5

(1R,3S)-1-benzo...

CAS#:629652-44-4

~81%

12-epi-Tadalafi...

CAS#:171596-27-3

Literature: Journal of Medicinal Chemistry, , vol. 46, # 21 p. 4533 - 4542

methylamine

CAS#:74-89-5

Chloropretadalafil

CAS#:171489-59-1

~1%

12-epi-Tadalafi...

CAS#:171596-27-3

Cialis

CAS#:171596-29-5

Literature: Bioorganic and Medicinal Chemistry, , vol. 12, # 6 p. 1505 - 1515

piperonal

CAS#:120-57-0

12-epi-Tadalafi...

CAS#:171596-27-3

Literature: Journal of Medicinal Chemistry, , vol. 46, # 21 p. 4533 - 4542

Methyl L-trypto...

CAS#:4299-70-1

12-epi-Tadalafi...

CAS#:171596-27-3

Literature: Journal of Medicinal Chemistry, , vol. 46, # 21 p. 4533 - 4542

(1R,3S)-1-(1,3-...

CAS#:171596-44-4

12-epi-Tadalafi...

CAS#:171596-27-3

Literature: Journal of Medicinal Chemistry, , vol. 46, # 21 p. 4533 - 4542

H-D-Trp-OMe.HCl

CAS#:14907-27-8

12-epi-Tadalafi...

CAS#:171596-27-3

Literature: Bioorganic and Medicinal Chemistry, , vol. 12, # 6 p. 1505 - 1515

(1R,2S,3R)-(+)-...

CAS#:171596-41-1

12-epi-Tadalafi...

CAS#:171596-27-3

Literature: Bioorganic and Medicinal Chemistry, , vol. 12, # 6 p. 1505 - 1515

Precursor 9
CAS#:171596-29-5 Cialis CAS#:74-89-5 methylamine CAS#:629652-44-4 (1R,3S)-1-benzo... CAS#:171489-59-1 Chloropretadalafil
CAS#:120-57-0 piperonal CAS#:4299-70-1 Methyl L-trypto... CAS#:171596-44-4 (1R,3S)-1-(1,3-... CAS#:14907-27-8 H-D-Trp-OMe.HCl
CAS#:171596-41-1 (1R,2S,3R)-(+)-...
DownStream 0

UNII-E319TQ0B6R

cis-ent-Tadalafil

PYR403

12-epi-TadalafilTadalafil

Tadalafil Impurity 13

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

12-epi-TadalafilTadalafil

Use of 12-epi-TadalafilTadalafil

Names

12-epi-TadalafilTadalafil Biological Activity

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.