12-epi-TadalafilTadalafil

Modify Date: 2024-01-02 22:20:08

12-epi-TadalafilTadalafil structure	Common Name	12-epi-TadalafilTadalafil
	CAS Number	171596-27-3	Molecular Weight	389.40
	Density	1.51±0.1 g/cm3 (20 ºC 760 Torr)	Boiling Point	N/A
	Molecular Formula	C₂₂H₁₉N₃O₄	Melting Point	295-296 ºC
	MSDS	N/A	Flash Point	N/A

Use of 12-epi-TadalafilTadalafil

cis-Tadalafil is a PDE5 inhibitor (IC50: 0.09 μM). cis-Tadalafil can be used for research of cardiovascular diseases[1].

Name	(6R,12aS)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Synonym	More Synonyms

Description	cis-Tadalafil is a PDE5 inhibitor (IC50: 0.09 μM). cis-Tadalafil can be used for research of cardiovascular diseases[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Target	PDE5:0.09 μM (IC50)
In Vitro	cis-Tadalafil (Compound 12b) 抑制 PDE5，IC50 为 0.09 μM[1]。
References	[1]. Daugan A, et al. The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues. J Med Chem. 2003 Oct 9;46(21):4533-42.

Density	1.51±0.1 g/cm3 (20 ºC 760 Torr)
Melting Point	295-296 ºC
Molecular Formula	C₂₂H₁₉N₃O₄
Molecular Weight	389.40
Exact Mass	389.13800
PSA	74.87000
LogP	2.08710
Water Solubility	Insuluble (8.6E-3 g/L) (25 ºC)

Cialis

CAS#:171596-29-5

~95%

12-epi-Tadalafi...

CAS#:171596-27-3

Literature: Tetrahedron Asymmetry, , vol. 19, # 4 p. 435 - 442

methylamine

CAS#:74-89-5

(1R,3S)-1-benzo...

CAS#:629652-44-4

~81%

12-epi-Tadalafi...

CAS#:171596-27-3

Literature: Journal of Medicinal Chemistry, , vol. 46, # 21 p. 4533 - 4542

methylamine

CAS#:74-89-5

Chloropretadalafil

CAS#:171489-59-1

~1%

12-epi-Tadalafi...

CAS#:171596-27-3

Cialis

CAS#:171596-29-5

Literature: Bioorganic and Medicinal Chemistry, , vol. 12, # 6 p. 1505 - 1515

piperonal

CAS#:120-57-0

12-epi-Tadalafi...

CAS#:171596-27-3

Literature: Journal of Medicinal Chemistry, , vol. 46, # 21 p. 4533 - 4542

Methyl L-trypto...

CAS#:4299-70-1

12-epi-Tadalafi...

CAS#:171596-27-3

Literature: Journal of Medicinal Chemistry, , vol. 46, # 21 p. 4533 - 4542

(1R,3S)-1-(1,3-...

CAS#:171596-44-4

12-epi-Tadalafi...

CAS#:171596-27-3

Literature: Journal of Medicinal Chemistry, , vol. 46, # 21 p. 4533 - 4542

H-D-Trp-OMe.HCl

CAS#:14907-27-8

12-epi-Tadalafi...

CAS#:171596-27-3

Literature: Bioorganic and Medicinal Chemistry, , vol. 12, # 6 p. 1505 - 1515

(1R,2S,3R)-(+)-...

CAS#:171596-41-1

12-epi-Tadalafi...

CAS#:171596-27-3

Literature: Bioorganic and Medicinal Chemistry, , vol. 12, # 6 p. 1505 - 1515

Precursor 9
CAS#:171596-29-5 Cialis CAS#:74-89-5 methylamine CAS#:629652-44-4 (1R,3S)-1-benzo... CAS#:171489-59-1 Chloropretadalafil
CAS#:120-57-0 piperonal CAS#:4299-70-1 Methyl L-trypto... CAS#:171596-44-4 (1R,3S)-1-(1,3-... CAS#:14907-27-8 H-D-Trp-OMe.HCl
CAS#:171596-41-1 (1R,2S,3R)-(+)-...
DownStream 0

UNII-E319TQ0B6R

cis-ent-Tadalafil

PYR403

12-epi-TadalafilTadalafil

Tadalafil Impurity 13

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12-epi-TadalafilTadalafil

Use of 12-epi-TadalafilTadalafil

Names

12-epi-TadalafilTadalafil Biological Activity

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.