ly 272015 hydrochloride

Modify Date: 2025-08-28 15:24:40

ly 272015 hydrochloride Structure
ly 272015 hydrochloride structure
 Common Name ly 272015 hydrochloride
CAS Number 172895-15-7 Molecular Weight 372.88800
Density N/A Boiling Point N/A
Molecular Formula C21H25ClN2O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ly 272015 hydrochloride


LY-272015 hydrochloride is an orally active, specific 5-HT2B receptor antagonist. LY-272015 hydrochloride completely inhibits the phosphorylation of ERK2 induced by 5-HT or BW723C86. LY-272015 hydrochloride is antihypertensive in Deoxycorticosterone Acetate (DOCA)-salt-hypertensive rats[1][2].

 Names

Name 1-[(3,4-dimethoxyphenyl)methyl]-6-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
Synonym More Synonyms

 ly 272015 hydrochloride Biological Activity

Description LY-272015 hydrochloride is an orally active, specific 5-HT2B receptor antagonist. LY-272015 hydrochloride completely inhibits the phosphorylation of ERK2 induced by 5-HT or BW723C86. LY-272015 hydrochloride is antihypertensive in Deoxycorticosterone Acetate (DOCA)-salt-hypertensive rats[1][2].
Related Catalog
Target

5-HT2B Receptor

References

[1]. S W Watts, et al. 5-HT2B-receptor antagonist LY-272015 is antihypertensive in DOCA-salt-hypertensive rats. Am J Physiol. 1999 Mar;276(3):H944-52.

[2]. Kota Naito, et al. Signal Transduction Mechanism for Serotonin 5-HT2B Receptor-Mediated DNA Synthesis and Proliferation in Primary Cultures of Adult Rat Hepatocytes. Biol Pharm Bull. 2016;39(1):121-9.

 Chemical & Physical Properties

Molecular Formula C21H25ClN2O2
Molecular Weight 372.88800
Exact Mass 372.16000
PSA 46.28000
LogP 5.05380
Storage condition Store at +4°C

 Synonyms

ly-272,015
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Chemsrc provides ly 272015 hydrochloride(CAS#:172895-15-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of ly 272015 hydrochloride are included as well.>> amp version: ly 272015 hydrochloride

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