LY2389575 hydrochloride
Modify Date: 2024-01-22 15:56:51
LY2389575 hydrochloride structure
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Common Name | LY2389575 hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 885104-09-6 | Molecular Weight | 438.58 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H16BrCl3N4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of LY2389575 hydrochlorideLY2389575 hydrochloride is a selective and noncompetitive mGlu3 negative allosteric modulator (NAM), with an IC50 value of 190 nM. LY2389575 hydrochloride induces an increase in Mrc1 levels. LY2389575 hydrochloride also independently amplifies Amyloid beta (Aβ) toxicity and can be used in study of Alzheimer's disease[1][2][3]. |
| Name | LY 2389575 hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | LY2389575 hydrochloride is a selective and noncompetitive mGlu3 negative allosteric modulator (NAM), with an IC50 value of 190 nM. LY2389575 hydrochloride induces an increase in Mrc1 levels. LY2389575 hydrochloride also independently amplifies Amyloid beta (Aβ) toxicity and can be used in study of Alzheimer's disease[1][2][3]. |
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| Related Catalog | |
| Target |
mGluR3:190 nM (IC50) |
| In Vitro | LY2389575 hydrochloride (5 μM; 1 h) 诱导小胶质细胞中 Mrc1 的水平升高[2]。 Real Time qPCR[2] Cell Line: Microglial cells Concentration: 5 μM Incubation Time: 1 h Result: Increased levels of Mrc1. |
| References |
| Molecular Formula | C15H16BrCl3N4 |
|---|---|
| Molecular Weight | 438.58 |
| Exact Mass | 435.962372 |
| Hazard Codes | Xi |
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| 3-Pyrrolidinamine, 1-(5-bromo-2-pyrimidinyl)-N-[(2,4-dichlorophenyl)methyl]-, (3S)-, hydrochloride (1:1) |
| (3S)-1-(5-Bromo-2-pyrimidinyl)-N-(2,4-dichlorobenzyl)-3-pyrrolidinamine hydrochloride (1:1) |
| MFCD28133385 |