Corynoxine B

Modify Date: 2024-01-02 10:43:30

Corynoxine B Structure
Corynoxine B structure
 Common Name Corynoxine B
CAS Number 17391-18-3 Molecular Weight 384.469
Density 1.2±0.1 g/cm3 Boiling Point 560.8±50.0 °C at 760 mmHg
Molecular Formula C22H28N2O4 Melting Point N/A
MSDS N/A Flash Point 293.0±30.1 °C

 Use of Corynoxine B


Corynoxine B is an oxindole alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese); a Beclin-1-dependent autophagy inducer. IC50 value:Target: Autophagy inducerin vitro: Corynoxine B, a natural autophagy inducer, restores the deficient cytosolic translocation of HMGB1 and autophagy in cells overexpressing SNCA, which may be attributed to its ability to block SNCA-HMGB1 interaction [1].in vivo: Corynoxine B exhibited prolongation of the thiopental-induced hypnosis on oral administration in mice [2].

 Names

Name rhynchophylline
Synonym More Synonyms

 Corynoxine B Biological Activity

Description Corynoxine B is an oxindole alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese); a Beclin-1-dependent autophagy inducer. IC50 value:Target: Autophagy inducerin vitro: Corynoxine B, a natural autophagy inducer, restores the deficient cytosolic translocation of HMGB1 and autophagy in cells overexpressing SNCA, which may be attributed to its ability to block SNCA-HMGB1 interaction [1].in vivo: Corynoxine B exhibited prolongation of the thiopental-induced hypnosis on oral administration in mice [2].
Related Catalog
References

[1]. Song JX, et al. HMGB1 is involved in autophagy inhibition caused by SNCA/α-synuclein overexpression: a process modulated by the natural autophagy inducer corynoxine B. Autophagy. 2014 Jan;10(1):144-54.

[2]. Sakakibara I, et al. Effect of oxindole alkaloids from the hooks of Uncaria macrophylla on thiopental-induced hypnosis. Phytomedicine. 1998 Apr;5(2):83-6.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 560.8±50.0 °C at 760 mmHg
Molecular Formula C22H28N2O4
Molecular Weight 384.469
Flash Point 293.0±30.1 °C
Exact Mass 384.204895
PSA 67.87000
LogP 3.31
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.596
Storage condition -20°C

 Precursor & DownStream

Precursor  1

DownStream  0

 Synonyms

Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid, 6'-ethyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, (αE,3R,6'S,7'S,8'aS)-
Corynoxine B
Methyl (7β,16E)-16-(methoxymethylene)-2-oxocorynoxan-17-oate
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