Corynoxine

Modify Date: 2024-01-06 12:16:57

Corynoxine Structure
Corynoxine structure
 Common Name Corynoxine
CAS Number 6877-32-3 Molecular Weight 384.469
Density 1.2±0.1 g/cm3 Boiling Point 560.8±50.0 °C at 760 mmHg
Molecular Formula C22H28N2O4 Melting Point 166-168ºC
MSDS N/A Flash Point 293.0±30.1 °C

 Use of Corynoxine


Corynoxine is an enantiomer of Corynoxine B; induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells.IC50 value:Tareget: Autophagy inducerIn vivo, Cory promotes the formation of autophagosomes in the fat bodies of Drosophila. By inducing autophagy, Cory promotes the clearance of wild-type and A53T α-syn in inducible PC12 cells. Interestingly, different from its enantiomer Cory B, Cory induces autophagy through the Akt/mTOR pathway as evidenced by the reduction in the levels of phospho-Akt, phospho-mTOR and phospho-p70 S6 Kinase [1]. Corynoxine significantly decreased locomotor activity after oral administration to mice [2].

 Names

Name Corynoxine
Synonym More Synonyms

 Corynoxine Biological Activity

Description Corynoxine is an enantiomer of Corynoxine B; induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells.IC50 value:Tareget: Autophagy inducerIn vivo, Cory promotes the formation of autophagosomes in the fat bodies of Drosophila. By inducing autophagy, Cory promotes the clearance of wild-type and A53T α-syn in inducible PC12 cells. Interestingly, different from its enantiomer Cory B, Cory induces autophagy through the Akt/mTOR pathway as evidenced by the reduction in the levels of phospho-Akt, phospho-mTOR and phospho-p70 S6 Kinase [1]. Corynoxine significantly decreased locomotor activity after oral administration to mice [2].
Related Catalog
References

[1]. Chen LL, et al. Corynoxine, a natural autophagy enhancer, promotes the clearance of alpha-synuclein via Akt/mTOR pathway. J Neuroimmune Pharmacol. 2014 Jun;9(3):380-7.

[2]. Sakakibara I, et al. Effect on locomotion of indole alkaloids from the hooks of uncaria plants. Phytomedicine. 1999 Jul;6(3):163-8.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 560.8±50.0 °C at 760 mmHg
Melting Point 166-168ºC
Molecular Formula C22H28N2O4
Molecular Weight 384.469
Flash Point 293.0±30.1 °C
Exact Mass 384.204895
PSA 67.87000
LogP 3.31
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.596
Storage condition -20°C

 Synonyms

Methyl (16E)-16-(methoxymethylene)-2-oxocorynoxan-17-oate
Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid, 6'-ethyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, (αE,3S,6'S,7'S,8'aS)-
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