LY88074

Modify Date: 2024-01-05 21:12:01

LY88074 Structure
LY88074 structure
Common Name LY88074
CAS Number 177744-96-6 Molecular Weight 346.39900
Density N/A Boiling Point N/A
Molecular Formula C21H14O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of LY88074


LY88074 (Compound 88074) is a Raloxifene analog lacking the basic side chain. Raloxifene is a selective estrogen receptor modulator, and reduces fracture risk at least in part by improving the mechanical properties of bone in a cell- and estrogen receptor-independent manner[1].

 Names

Name (4-hydroxyphenyl)-[3-(4-hydroxyphenyl)-1-benzothiophen-2-yl]methanone

 LY88074 Biological Activity

Description LY88074 (Compound 88074) is a Raloxifene analog lacking the basic side chain. Raloxifene is a selective estrogen receptor modulator, and reduces fracture risk at least in part by improving the mechanical properties of bone in a cell- and estrogen receptor-independent manner[1].
Related Catalog
In Vitro Removal of the aminoethylpiperdine moiety, as in LY88074 (Compound 88074), reduces bone binding, compared to Raloxifene. The interaction of LY88074 with collagen matrix, although significant, is less than the interaction found with Raloxifene[1].
References

[1]. Bivi N, et al. Structural features underlying raloxifene's biophysical interaction with bone matrix. Bioorg Med Chem. 2016 Feb 15;24(4):759-67.

 Chemical & Physical Properties

Molecular Formula C21H14O4S
Molecular Weight 346.39900
Exact Mass 346.06600
PSA 85.77000
LogP 5.21050
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