Sauchinone
Modify Date: 2025-09-06 09:44:09
Sauchinone structure
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Common Name | Sauchinone | ||
|---|---|---|---|---|
| CAS Number | 177931-17-8 | Molecular Weight | 356.369 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 498.1±45.0 °C at 760 mmHg | |
| Molecular Formula | C20H20O6 | Melting Point | 224-226℃ | |
| MSDS | Chinese USA | Flash Point | 220.3±28.8 °C | |
Use of SauchinoneSauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity[1]. |
| Name | (5aR,7R,8S,8aR,14aS,14bR)-7,8-Dimethyl-5a,6,7,8,8a,14b-hexahydro- 5H-benzo[kl]bis[1,3]dioxolo[4,5-b:4',5'-g]xanthen-5-one |
|---|---|
| Synonym | More Synonyms |
| Description | Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity[1]. |
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| Related Catalog | |
| Target |
p65 I-kappaBalpha |
| In Vitro | Sauchinone (1, 3, 10, 30μm; 6 hours) inhibits LPS-inducible increase in the iNOS mRNA in Raw264.7 cells[1]. Sauchinone at the concentrations of 3 and 30 μm inhibits TNF-α production in LPS-treated cells by 40 and 50%, respectively[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 498.1±45.0 °C at 760 mmHg |
| Melting Point | 224-226℃ |
| Molecular Formula | C20H20O6 |
| Molecular Weight | 356.369 |
| Flash Point | 220.3±28.8 °C |
| Exact Mass | 356.125977 |
| PSA | 63.22000 |
| LogP | 3.81 |
| Appearance of Characters | white to beige |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.643 |
| Storage condition | 2-8°C |
| Water Solubility | DMSO: soluble5mg/mL, clear (warmed) |
| Safety Phrases | 24/25 |
|---|---|
| RIDADR | NONH for all modes of transport |
| HS Code | 29329990 |
| (5aR,7R,8S,8aR,14aS,14bR)-7,8-Dimethyl-5a,6,7,8,8a,14b-hexahydro-5H-benzo[kl]bis[1,3]dioxolo[4,5-b:4',5'-g]xanthen-5-one |
| Sauchinone |
| 5H-Benzo[kl][1,3]dioxolo[4,5-b]-1,3-dioxolo[4,5-g]xanthen-5-one, 5a,6,7,8,8a,14b-hexahydro-7,8-dimethyl-, (5aR,7R,8S,8aR,14aS,14bR)- |
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- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Sauchinone
- Price: Check
- Purity: 98.0%
- Delivery: 10 Day
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- BioBioPha
- China
- Product Name: Sauchinone
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- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Sauchinone
- Price: ￥788.0/20mg
- Purity: 98.0%
- Delivery: 1 Day
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- DC Chemicals Limited
- China
- Product Name: sauchinone
- Price: $280.0/20mg
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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Price: ￥800/5 mg
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