MRT67307 dihydrochloride

Modify Date: 2024-01-21 12:02:17

MRT67307 dihydrochloride structure	Common Name	MRT67307 dihydrochloride
	CAS Number	1781882-89-0	Molecular Weight	537.52
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₃₈Cl₂N₆O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MRT67307 dihydrochloride

MRT67307 dihydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively[1]. MRT67307 dihydrochloride also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 dihydrochloride also blocks autophagy in cells[2].

Name	MRT67307 dihydrochloride

Description	MRT67307 dihydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively[1]. MRT67307 dihydrochloride also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 dihydrochloride also blocks autophagy in cells[2].
Related Catalog	Signaling Pathways >> NF-κB >> IKK Research Areas >> Cancer Signaling Pathways >> Autophagy >> ULK Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Inflammation/Immunology
References	[1]. Clark K, et al. Novel cross-talk within the IKK family controls innate immunity. Biochem J. 2011 Feb 15;434(1):93-104. [2]. Petherick KJ, et al. Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J Biol Chem. 2015 May 1;290(18):11376-83.

Description

Related Catalog

Signaling Pathways >> NF-κB >> IKK

Research Areas >> Cancer

Signaling Pathways >> Autophagy >> ULK

Signaling Pathways >> Autophagy >> Autophagy

Research Areas >> Inflammation/Immunology

References

[1]. Clark K, et al. Novel cross-talk within the IKK family controls innate immunity. Biochem J. 2011 Feb 15;434(1):93-104.

[2]. Petherick KJ, et al. Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J Biol Chem. 2015 May 1;290(18):11376-83.