Nav1.7-IN-3

Modify Date: 2024-01-10 11:59:39

Nav1.7-IN-3 structure	Common Name	Nav1.7-IN-3
	CAS Number	1788872-06-9	Molecular Weight	430.95
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₂₀ClFN₄O₂S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Nav1.7-IN-3

Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC50 of 8 nM. Pain relief. Limited CNS penetration[1].

Name	Nav1.7-IN-3

Description	Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC50 of 8 nM. Pain relief. Limited CNS penetration[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease
Target	IC50: 8 nM (Nav1.7)[1]
In Vivo	Nav1.7-IN-3 (compound 5) shows excellent potency, selectivity, behavioral efficacy in a rodent pain model (30 mg/kg, oral, 35 minutes), and efficacy in a mouse itch model (30 mg/kg, oral, 30 minutes)[1]. Animal Model: C57BL/6 male mice (n=8/group, 25-30g) Dosage: 1, 3, and 10 mg/kg Administration: Oral (0-35 mintues) Result: Nav1.7-IN-3 demonstrates statistically significant, dose-dependent reversal of these effects in the acute phase of the experiment (0-5 min period post formalin injection) and the tonic phase of the experiment (20-35 min period post formalin injection) with full reversal of formalin effects in the tonic phase[1]
References	[1]. Roecker AJ, et al. Discovery of selective, orally bioavailable, N-linked arylsulfonamide Nav1.7 inhibitors with pain efficacy in mice. Bioorg Med Chem Lett. 2017 May 15;27(10):2087-2093.

Molecular Formula	C₁₇H₂₀ClFN₄O₂S₂
Molecular Weight	430.95

DC Chemicals Limited
China
Product Name: Nav1.7-IN-3
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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