Nav1.7-IN-2

Modify Date: 2024-01-14 15:23:13

Nav1.7-IN-2 Structure
Nav1.7-IN-2 structure
Common Name Nav1.7-IN-2
CAS Number 1332295-35-8 Molecular Weight 407.441
Density 1.3±0.1 g/cm3 Boiling Point N/A
Molecular Formula C22H22FN5O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Nav1.7-IN-2


Nav1.7-IN-2 is an inhibitor of voltage-gated sodium channels (Nav), in particular Nav 1.7, with IC50 of 80 nM.IC50 value: 80 nMTarget: Nav 1.7Nav1.7-IN-2 is useful for the treatment of diseases treatable by inhibition of these channels, in particular, chronic pain disorder. The more detailed information please refer to WO 2011103196 A1. Nav1.7-IN-2 is a Nav1.7 channel inhibitor extracted from patent WO/2011103196 A1, compound example J, has an IC50 of 80 nM.

 Names

Name Nav1.7-IN-2
Synonym More Synonyms

 Nav1.7-IN-2 Biological Activity

Description Nav1.7-IN-2 is an inhibitor of voltage-gated sodium channels (Nav), in particular Nav 1.7, with IC50 of 80 nM.IC50 value: 80 nMTarget: Nav 1.7Nav1.7-IN-2 is useful for the treatment of diseases treatable by inhibition of these channels, in particular, chronic pain disorder. The more detailed information please refer to WO 2011103196 A1. Nav1.7-IN-2 is a Nav1.7 channel inhibitor extracted from patent WO/2011103196 A1, compound example J, has an IC50 of 80 nM.
Related Catalog
References

[1]. Bregman Howard, et al. Preparation of aryl carboxamide derivatives as sodium channel inhibitors for treatment of pain. From PCT Int. Appl. (2011), WO 2011103196 A1 20110825.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Molecular Formula C22H22FN5O2
Molecular Weight 407.441
Exact Mass 407.175751
LogP 2.32
Index of Refraction 1.646
Storage condition 2-8℃

 Synonyms

3-({4-[3-(4-Fluoro-2-methylphenoxy)-1-azetidinyl]-2-pyrimidinyl}amino)-N-methylbenzamide
Benzamide, 3-[[4-[3-(4-fluoro-2-methylphenoxy)-1-azetidinyl]-2-pyrimidinyl]amino]-N-methyl-
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