OAT-177
Modify Date: 2023-01-26 10:12:47
OAT-177 structure
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Common Name | OAT-177 | ||
|---|---|---|---|---|
| CAS Number | 1799548-33-6 | Molecular Weight | 376.933 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H29ClN6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of OAT-177OAT-177 is a potent, selective, orally active acidic mammalian chitinase (AMCase) inhibitor with IC50 of 14 and 19 nM against human and mouse AMCas, respectively, >150-fold selectivity over mCHIT1; shows significant anti-inflammatory efficacy in HDM-induced allergic airway inflammation in mice at 30 mg/kg po, reduces inflammatory cell influx in the BALF and total IgE concentration in plasma. |
| Name | OAT-177 |
|---|
| Description | OAT-177 is a potent, selective, orally active acidic mammalian chitinase (AMCase) inhibitor with IC50 of 14 and 19 nM against human and mouse AMCas, respectively, >150-fold selectivity over mCHIT1; shows significant anti-inflammatory efficacy in HDM-induced allergic airway inflammation in mice at 30 mg/kg po, reduces inflammatory cell influx in the BALF and total IgE concentration in plasma. |
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| References | References 1. Mazur M, et al. J Med Chem. 2018 Feb 8;61(3):695-710. View Related Products by Target Other Targets |
| Molecular Formula | C19H29ClN6 |
|---|---|
| Molecular Weight | 376.933 |