Name | SEN177 |
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Synonyms |
3',3'']terpyridine
SEN177 MFCD30343871 Piperidine, 1-(6'-fluoro[3,3'-bipyridin]-2-yl)-4-(4-methyl-4H-1,2,4-triazol-3-yl)- 6'-Fluoro-2-[4-(4-methyl-4H-1,2,4-triazol-3-yl)-1-piperidinyl]-3,3'-bipyridine 6''-Fluoro-4-(4-methyl-4H-[1,2,4]triazol-3-yl)-3,4,5,6-tetrahydro-2H-[1,2' 6''-fluoro-4-(4-methyl-4H-[1,2,4]triazol-3-yl)-3,4,5,6-tetrahydro-2H-[1,2';3',3'']terpyridine |
Description | SEN177 is an inhibitor of glutaminyl cyclase (QPCT), thereby rescuing the Huntington's disease (HD)-related phenotypes in cell. |
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In Vitro | SEN177 is a Glutaminyl cyclase (QPCT) inhibitor. Glutaminyl cyclase modifies N-terminal glutamine or glutamate residues to N-terminal 5-oxoproline or pyroglutamate (named QPCT). QPCT inhibits mutant huntingtin from forming aggregates, but also reduces aggregation of other aggregate-prone proteins containing polyQ or polyA repeats. SEN177 caused dose-dependent decreases in HTT aggregation by a mechanism that requires QPCT inhibition. SEN177 had in vitro activity against polyglutamine toxicity and was able to reduce aggregates in mammalian cells, primary neurons and in a Drosophila model. |
Density | 1.4±0.1 g/cm3 |
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Boiling Point | 581.3±60.0 °C at 760 mmHg |
Molecular Formula | C18H19FN6 |
Molecular Weight | 338.382 |
Flash Point | 305.3±32.9 °C |
Exact Mass | 338.165527 |
LogP | 1.12 |
Vapour Pressure | 0.0±1.6 mmHg at 25°C |
Index of Refraction | 1.683 |