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  • DC Chemicals Limited
  • China
  • Product Name: SEN-177
  • Price: $700.0/100mg $1200.0/250mg $2700.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

2117405-13-5

2117405-13-5 structure
2117405-13-5 structure
  • Name: SEN-177
  • Chemical Name: SEN177
  • CAS Number: 2117405-13-5
  • Molecular Formula: C18H19FN6
  • Molecular Weight: 338.382
  • Catalog: Research Areas Neurological Disease
  • Create Date: 2020-01-11 17:36:51
  • Modify Date: 2024-01-16 17:10:33
  • SEN177 is an inhibitor of glutaminyl cyclase (QPCT), thereby rescuing the Huntington's disease (HD)-related phenotypes in cell.

Name SEN177
Synonyms 3',3'']terpyridine
SEN177
MFCD30343871
Piperidine, 1-(6'-fluoro[3,3'-bipyridin]-2-yl)-4-(4-methyl-4H-1,2,4-triazol-3-yl)-
6'-Fluoro-2-[4-(4-methyl-4H-1,2,4-triazol-3-yl)-1-piperidinyl]-3,3'-bipyridine
6''-Fluoro-4-(4-methyl-4H-[1,2,4]triazol-3-yl)-3,4,5,6-tetrahydro-2H-[1,2'
6''-fluoro-4-(4-methyl-4H-[1,2,4]triazol-3-yl)-3,4,5,6-tetrahydro-2H-[1,2';3',3'']terpyridine
Description SEN177 is an inhibitor of glutaminyl cyclase (QPCT), thereby rescuing the Huntington's disease (HD)-related phenotypes in cell.
In Vitro SEN177 is a Glutaminyl cyclase (QPCT) inhibitor. Glutaminyl cyclase modifies N-terminal glutamine or glutamate residues to N-terminal 5-oxoproline or pyroglutamate (named QPCT). QPCT inhibits mutant huntingtin from forming aggregates, but also reduces aggregation of other aggregate-prone proteins containing polyQ or polyA repeats. SEN177 caused dose-dependent decreases in HTT aggregation by a mechanism that requires QPCT inhibition. SEN177 had in vitro activity against polyglutamine toxicity and was able to reduce aggregates in mammalian cells, primary neurons and in a Drosophila model.
Density 1.4±0.1 g/cm3
Boiling Point 581.3±60.0 °C at 760 mmHg
Molecular Formula C18H19FN6
Molecular Weight 338.382
Flash Point 305.3±32.9 °C
Exact Mass 338.165527
LogP 1.12
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.683