1799548-33-6
1799548-33-6 structure
- Name: OAT-177
- Chemical Name: OAT-177
- CAS Number: 1799548-33-6
- Molecular Formula: C19H29ClN6
- Molecular Weight: 376.933
- Create Date: 2020-01-12 07:07:49
- Modify Date: 2024-09-12 15:20:46
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OAT-177 is a potent, selective, orally active acidic mammalian chitinase (AMCase) inhibitor with IC50 of 14 and 19 nM against human and mouse AMCas, respectively, >150-fold selectivity over mCHIT1; shows significant anti-inflammatory efficacy in HDM-induced allergic airway inflammation in mice at 30 mg/kg po, reduces inflammatory cell influx in the BALF and total IgE concentration in plasma.
| Name | OAT-177 |
|---|
| Description | OAT-177 is a potent, selective, orally active acidic mammalian chitinase (AMCase) inhibitor with IC50 of 14 and 19 nM against human and mouse AMCas, respectively, >150-fold selectivity over mCHIT1; shows significant anti-inflammatory efficacy in HDM-induced allergic airway inflammation in mice at 30 mg/kg po, reduces inflammatory cell influx in the BALF and total IgE concentration in plasma. |
|---|---|
| References | References 1. Mazur M, et al. J Med Chem. 2018 Feb 8;61(3):695-710. View Related Products by Target Other Targets |
| Molecular Formula | C19H29ClN6 |
|---|---|
| Molecular Weight | 376.933 |