endo-BCN-PEG4-NHS ester

Modify Date: 2024-01-16 12:56:35

endo-BCN-PEG4-NHS ester Structure
endo-BCN-PEG4-NHS ester structure
Common Name endo-BCN-PEG4-NHS ester
CAS Number 1807501-86-5 Molecular Weight 538.587
Density 1.3±0.1 g/cm3 Boiling Point N/A
Molecular Formula C26H38N2O10 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of endo-BCN-PEG4-NHS ester


endo-BCN-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name endo-BCN-PEG4-NHS ester
Synonym More Synonyms

 endo-BCN-PEG4-NHS ester Biological Activity

Description endo-BCN-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Molecular Formula C26H38N2O10
Molecular Weight 538.587
Exact Mass 538.252625
LogP -0.81
Index of Refraction 1.544

 Synonyms

MFCD23704191
(1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl {15-[(2,5-dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl}carbamate
Carbamic acid, N-[15-[(2,5-dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl]-, (1R,8S)-bicyclo[6.1.0]non-4-yn-9-ylmethyl ester
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