GNE-140 racemic
Modify Date: 2025-08-25 18:07:56
GNE-140 racemic structure
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Common Name | GNE-140 racemic | ||
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| CAS Number | 1809794-70-4 | Molecular Weight | 499.04 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H23ClN2O3S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GNE-140 racemicGNE-140 racemic is a novel potent lactate dehydrogenase (LDHA) inhibitor. In MIA PaCa-2 human pancreatic cells, LDHA inhibition rapidly affected global metabolism, although cell death only occurred after 2 d of continuous LDHA inhibition. Pancreatic cell lines that utilize oxidative phosphorylation (OXPHOS) rather than glycolysis were inherently resistant to GNE-140, but could be resensitized to GNE-140 with the OXPHOS inhibitor phenformin. Acquired resistance to GNE-140 was driven by activation of the AMPK-mTOR-S6K signaling pathway, which led to increased OXPHOS, and inhibitors targeting this pathway could prevent resistance. |
| Name | GNE-140 racemic |
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| Description | GNE-140 racemic is a novel potent lactate dehydrogenase (LDHA) inhibitor. In MIA PaCa-2 human pancreatic cells, LDHA inhibition rapidly affected global metabolism, although cell death only occurred after 2 d of continuous LDHA inhibition. Pancreatic cell lines that utilize oxidative phosphorylation (OXPHOS) rather than glycolysis were inherently resistant to GNE-140, but could be resensitized to GNE-140 with the OXPHOS inhibitor phenformin. Acquired resistance to GNE-140 was driven by activation of the AMPK-mTOR-S6K signaling pathway, which led to increased OXPHOS, and inhibitors targeting this pathway could prevent resistance. |
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| Molecular Formula | C25H23ClN2O3S2 |
|---|---|
| Molecular Weight | 499.04 |
| InChIKey | SUFXXEIVBZJOAP-UHFFFAOYSA-N |
| SMILES | O=C1NC(c2ccc(N3CCOCC3)cc2)(c2ccsc2)CC(O)=C1Sc1ccccc1Cl |