GNE-9605
Modify Date: 2024-01-02 08:13:57
GNE-9605 structure
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Common Name | GNE-9605 | ||
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| CAS Number | 1536200-31-3 | Molecular Weight | 449.834 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 587.9±60.0 °C at 760 mmHg | |
| Molecular Formula | C17H20ClF4N7O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 309.4±32.9 °C | |
Use of GNE-9605GNE-9605 is a highly potent, selective, and brain-penetrant LRRK2 inhibitor with IC50 of 19 nM.IC50 value:Target: LRRK2GNE-9605 retained excellent predicted human metabolic stability when assayed in human liver microsomes and hepatocytes. Inaddition, no reversible or time-dependent inhibition of any of the major CYP isoforms was observed. The demonstrated metabolic stability, brain penetration across multiple species, and selectivity of these inhibitors support their use in preclinical efficacy and safety studies. |
| Name | 2,4-Pyrimidinediamine, N2-[5-chloro-1-[(3R,4R)-3-fluoro-1-(3-oxetanyl)-4-piperidinyl]-1H-pyrazol-4-yl]-N4-methyl-5-(trifluoromethyl)-, rel |
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| Synonym | More Synonyms |
| Description | GNE-9605 is a highly potent, selective, and brain-penetrant LRRK2 inhibitor with IC50 of 19 nM.IC50 value:Target: LRRK2GNE-9605 retained excellent predicted human metabolic stability when assayed in human liver microsomes and hepatocytes. Inaddition, no reversible or time-dependent inhibition of any of the major CYP isoforms was observed. The demonstrated metabolic stability, brain penetration across multiple species, and selectivity of these inhibitors support their use in preclinical efficacy and safety studies. |
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| Related Catalog | |
| References |
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 587.9±60.0 °C at 760 mmHg |
| Molecular Formula | C17H20ClF4N7O |
| Molecular Weight | 449.834 |
| Flash Point | 309.4±32.9 °C |
| Exact Mass | 449.135406 |
| PSA | 80.13000 |
| LogP | 1.15 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.663 |
| Storage condition | 2-8℃ |
| 2,4-Pyrimidinediamine, N-[5-chloro-1-[(3S,4S)-3-fluoro-1-(3-oxetanyl)-4-piperidinyl]-1H-pyrazol-4-yl]-N-methyl-5-(trifluoromethyl)- |
| N-{5-Chloro-1-[(3S,4S)-3-fluoro-1-(3-oxetanyl)-4-piperidinyl]-1H-pyrazol-4-yl}-N-methyl-5-(trifluoromethyl)-2,4-pyrimidinediamine |
| GNE-9605 |