GNE-490
Modify Date: 2024-01-02 12:53:16
GNE-490 structure
|
Common Name | GNE-490 | ||
|---|---|---|---|---|
| CAS Number | 1033739-92-2 | Molecular Weight | 386.47 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 595.3±60.0 °C at 760 mmHg | |
| Molecular Formula | C18H22N6O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 313.9±32.9 °C | |
Use of GNE-490GNE-490, a (thienopyrimidin-2-yl)aminopyrimidine, is a potent pan-PI3K inhibitor with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively. GNE-490 has >200 fold selectivity for mTOR (IC50=750 nM). GNE-490 shows potent suppression efficacy profile against MCF7.1 breast cancer xenograft model[1]. |
| Name | 2-[2-(2-Amino-4-methyl-5-pyrimidinyl)-4-(4-morpholinyl)thieno[3,2 -d]pyrimidin-6-yl]-2-propanol |
|---|---|
| Synonym | More Synonyms |
| Description | GNE-490, a (thienopyrimidin-2-yl)aminopyrimidine, is a potent pan-PI3K inhibitor with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively. GNE-490 has >200 fold selectivity for mTOR (IC50=750 nM). GNE-490 shows potent suppression efficacy profile against MCF7.1 breast cancer xenograft model[1]. |
|---|---|
| Related Catalog | |
| Target |
PI3Kα:3.5 nM (IC50) PI3Kβ:25 nM (IC50) PI3Kδ:5.2 nM (IC50) PI3Kγ:15 nM (IC50) mTOR:750 nM (IC50) |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 595.3±60.0 °C at 760 mmHg |
| Molecular Formula | C18H22N6O2S |
| Molecular Weight | 386.47 |
| Flash Point | 313.9±32.9 °C |
| Exact Mass | 386.152496 |
| PSA | 139.25000 |
| LogP | 1.48 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.676 |
| Storage condition | 2-8℃ |
| 3,6,9,12,15,18-Hexaoxanonacosan-1-ol |
| Thieno[3,2-d]pyrimidine-6-methanol, 2-(2-amino-4-methyl-5-pyrimidinyl)-α,α-dimethyl-4-(4-morpholinyl)- |
| alcohol ethoxylate |
| 2-[2-(2-Amino-4-methyl-5-pyrimidinyl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]-2-propanol |