Cyclotriazadisulfonamide
Modify Date: 2024-01-09 19:00:16
Cyclotriazadisulfonamide structure
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Common Name | Cyclotriazadisulfonamide | ||
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| CAS Number | 182316-44-5 | Molecular Weight | 581.78900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C31H39N3O4S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CyclotriazadisulfonamideCyclotriazadisulfonamide (CADA) is a specific CD4-targeted HIV entry inhibitors. Cyclotriazadisulfonamide (CADA) inhibits the co-translational translocation of human CD4 (huCD4) into the ER lumen in a signal peptide (SP)-dependent way[1][2]. |
| Name | 9-benzyl-3-methylene-1,5-ditosyl-1,5,9-triazacyclododecane (CADA) |
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| Synonym | More Synonyms |
| Description | Cyclotriazadisulfonamide (CADA) is a specific CD4-targeted HIV entry inhibitors. Cyclotriazadisulfonamide (CADA) inhibits the co-translational translocation of human CD4 (huCD4) into the ER lumen in a signal peptide (SP)-dependent way[1][2]. |
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| Related Catalog | |
| In Vitro | Cyclotriazadisulfonamide (CADA) significantly decreases the amount of cell surface CD4 -the main receptor for HIV -without altering the expression of any other cellular receptor examined so far[1]. Cyclotriazadisulfonamide (CADA) exhibits an EC50 of 0.4 μg/mL for CD4 in MO-DC cells. Treatment of MO-DC with 10 μg/mL of CADA results in 83% downregulation of cell surface CD4, an effect that is similar to that observed for CADA treatment of CD4+ T cells[1]. CADA prevents MT-4 cells from HIV-1 and SIV infection (EC50 are 0.7 and 1.2 g/ml, respectively)[1]. Western Blot Analysis[1] Cell Line: MO-DCs. Concentration: 0.4 μg/mL. Incubation Time: 24 h. Result: A 50% reduction in CD4 expression was obtained. |
| References |
| Molecular Formula | C31H39N3O4S2 |
|---|---|
| Molecular Weight | 581.78900 |
| Exact Mass | 581.23800 |
| PSA | 94.76000 |
| LogP | 6.81250 |
| Hazard Codes | Xi |
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| 9-benzyl-3-methylene-1,5-ditosyl-1,5,9-triazacyclododecane |
| CADA |
| 9-Benzyl-3-methylene-1,5-bis-(toluene-4-sulfonyl)-1,5,9-triaza-cyclododecane |
| 9-benzyl-3-methylene-1,5-bis(4-methylbenzenesulfonyl)-1,5,9-triazacyclododecane |