Captisol
Modify Date: 2024-01-02 11:04:27
Captisol structure
|
Common Name | Captisol | ||
|---|---|---|---|---|
| CAS Number | 182410-00-0 | Molecular Weight | 1451.287 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C50H84Na2O41S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of CaptisolSBE-β-CD is a sulfobutylether β-cyclodextrin derivative used as an excipient or a formulating agent to increase the solubility of poorly soluble drugs. |
| Name | Captisol |
|---|---|
| Synonym | More Synonyms |
| Description | SBE-β-CD is a sulfobutylether β-cyclodextrin derivative used as an excipient or a formulating agent to increase the solubility of poorly soluble drugs. |
|---|---|
| Related Catalog | |
| In Vitro | SBE-β-CD is a chemically modified β-CD that is a cyclic hydrophilic oligosaccharide which is negatively charged in aqueous media. β-CD functioned is a solubilizer only at low concentrations, whereas SBE7-β-CD exhibits strong solubilizing effects over a wide concentration range[1]. |
| In Vivo | SBE-β-CD is a derivatized form of β-cyclodextrin that has been developed as a safe and effective solubilizing agent for drugs being administered by parenteral and other routes (including oral). SBE-β-CD is a cyclic carbohydrate comprised of seven glucose molecules; the resulting truncated cone-like structure being further derivatized with an average of seven sulfobutyl ether groups[2]. The calorimetric data for the Compound 1/SBE-β-CD complex indicates an extremely strong interaction, with an association constant of 2.3±(0.2)×106M-1 at 25°C and 1.6±(0.2)×106M-1 at 37°C[3]. SBE-β-CD alone evokes a mild cardio-depressant effect independent of cocaine treatment (p=0.0001 compared to baseline) but attenuates further cocaine-induced decreases in RPP, dP/dtmax, and dP/dtmaxabs at high cocaine concentrations. No significant effect is seen on line pressure SBE-β-CD alleviates the most pronounced cardiac depression for RPP, dP/dtmax, and dP/dtmaxabs. This differential effect of SBE-β-CD at low and high concentrations produces an interaction effect in the two-way ANOVA for RPP (p<0.0001), dP/dtmax (p=0.0001), and dP/dtmaxabs (p=0.0015), and prevents any overall treatment effect. Infusing SBE-β-CD also attenuates the cardiac depression associated with cocaethylene toxicity for RPP and dP/dtmax. No differences are observed between ethanol-treated controls and cocaethylene plus SBE-β-CD groups[4]. |
| Animal Admin | Rats[3] A 300 g rat is administered with 1 mL of a 0.1 M SBE-β-CD solution containing 5.64 mg of Compound 1, and assuming an extracellular volume of 90 mL, less than 0.1% of the complex would rapidly dissociate due to the initial effects of dilution. This calculation, combined with the changing blood to plasma ratio in the presence of SBE-β-CD, provides a reasonable explanation for the observed differences in the blood and plasma profiles of Compound 1 after intravenous administration in either the cyclodextrin or cyclodextrin-free formulations. After IV administration of the cyclodextrin formulation, Compound 1 would initially be prevented from distributing into erythrocytes thereby resulting in a whole blood to plasma ratio of less than one. Subsequently, clearance of SBE-β-CD from the circulation would lead to changes in the complexation equilibrium such that the unbound fraction of Compound 1 would increase, thereby reestablishing normal blood to plasma partitioning (i.e. in favour of whole blood) and clearance. |
| References |
| Molecular Formula | C50H84Na2O41S2 |
|---|---|
| Molecular Weight | 1451.287 |
| Exact Mass | 1450.372437 |
| PSA | 663.21000 |
| Appearance of Characters | Solid powder | White to off white |
| Storage condition | 2-8℃ |
| Water Solubility | Soluble in water.Insoluble in acetone, methanol, chloroform. |
| Disodium 4-({36,38,39,40,41,42,43,44,45,46,47,48,49-tridecahydroxy-5,10,15,20,25,30-hexakis(hydroxymethyl)-35-[(4-sulfonatobutoxy)methyl]-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31 ;.2.2.2.2.2.2.2.2]nonatetracont-37-yl}oxy)-1-butanesulfonate |
| CS-0731 |
| Sodium Sulphobutylether-beta-cyclodextrin |
| SBE-Beta-CD |
| sulfobutyl ether-beta-cyclodextrin sodium salt |
| SBE-β-CD |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Captisol
- Price: Click To Check
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Captisol
- Price: ￥168.0/5g ￥118.0/1g
- Purity: 97.0%
- Delivery: 2 Day
- Contact: Liu jia
- Email: 2130147988@qq.com
- DC Chemicals Limited
- China
- Product Name: SBE-β-CD
- Price: $200.0/100mg $350.0/250mg $650.0/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: SBE-β-CD
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Beta-cyclodextrin Sulfobutyl Ether Sodium
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: sulfobutyl ether-beta-cyclodextrin
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Delivery: Inquiry
- Contact: Anson
- Email: info@tianfuchem.com
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