Smurf1-IN-1

Modify Date: 2025-08-26 04:57:03

Smurf1-IN-1 Structure
Smurf1-IN-1 structure
 Common Name Smurf1-IN-1
CAS Number 1824708-03-3 Molecular Weight 468.98
Density N/A Boiling Point N/A
Molecular Formula C24H29ClN6O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Smurf1-IN-1


Smurf1-IN-1 is an orally active and selective inhibitor of specific E3 ubiquitin protein ligase 1 (SMURF1) with an IC50 of 92 nM. Smurf1-IN-1 has significant efficacy in rats model of pulmonary hypertension[1].

 Names

Name Smurf1-IN-1

 Smurf1-IN-1 Biological Activity

Description Smurf1-IN-1 is an orally active and selective inhibitor of specific E3 ubiquitin protein ligase 1 (SMURF1) with an IC50 of 92 nM. Smurf1-IN-1 has significant efficacy in rats model of pulmonary hypertension[1].
Related Catalog
Target

IC50: 92 nM Specific E3ubiquitin protein ligase 1 (SMURF1)[1]

References

[1]. Shaw DE, et.al. Design and Synthesis of Inhibitors of the E3 Ligase SMAD Specific E3 Ubiquitin Protein Ligase 1 as a Treatment for Lung Remodeling in Pulmonary Arterial Hypertension. J Med Chem. 2023 Jun 22;66(12):8130-8139.  

 Chemical & Physical Properties

Molecular Formula C24H29ClN6O2
Molecular Weight 468.98
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Chemsrc provides Smurf1-IN-1(CAS#:1824708-03-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Smurf1-IN-1 are included as well.>> amp version: Smurf1-IN-1

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