Smurf1-IN-1

Modify Date: 2025-08-26 04:57:03

Smurf1-IN-1 structure	Common Name	Smurf1-IN-1
	CAS Number	1824708-03-3	Molecular Weight	468.98
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₉ClN₆O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Smurf1-IN-1

Smurf1-IN-1 is an orally active and selective inhibitor of specific E3 ubiquitin protein ligase 1 (SMURF1) with an IC50 of 92 nM. Smurf1-IN-1 has significant efficacy in rats model of pulmonary hypertension[1].

Name	Smurf1-IN-1

Description	Smurf1-IN-1 is an orally active and selective inhibitor of specific E3 ubiquitin protein ligase 1 (SMURF1) with an IC50 of 92 nM. Smurf1-IN-1 has significant efficacy in rats model of pulmonary hypertension[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> E1/E2/E3 Enzyme
Target	IC50: 92 nM Specific E3ubiquitin protein ligase 1 (SMURF1)[1]
References	[1]. Shaw DE, et.al. Design and Synthesis of Inhibitors of the E3 Ligase SMAD Specific E3 Ubiquitin Protein Ligase 1 as a Treatment for Lung Remodeling in Pulmonary Arterial Hypertension. J Med Chem. 2023 Jun 22;66(12):8130-8139.

Molecular Formula	C₂₄H₂₉ClN₆O₂
Molecular Weight	468.98

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