L-Homocystine
L-Homocystine structure
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Common Name | L-Homocystine | ||
|---|---|---|---|---|
| CAS Number | 626-72-2 | Molecular Weight | 268.354 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 507.6±50.0 °C at 760 mmHg | |
| Molecular Formula | C8H16N2O4S2 | Melting Point | 281-284ºC (dec.) | |
| MSDS | Chinese USA | Flash Point | 260.8±30.1 °C | |
Use of L-HomocystineL-Homocystine is the oxidized member of the L-homocysteine. Homocysteine is a pro-thrombotic factor, vasodilation impairing agent, pro-inflammatory factor and endoplasmatic reticulum-stress inducer used to study cardiovascular disease mechanisms. |
Summary: L-Homocystine (Chinese name: L-高胱氨酸), CAS number 626-72-2, molecular formula C8H16N2O4S2, molecular weight 268.354, used for studying the mechanism of cardiovascular disease development. For research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | L-Homocystine |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | L-Homocystine is the oxidized member of the L-homocysteine. Homocysteine is a pro-thrombotic factor, vasodilation impairing agent, pro-inflammatory factor and endoplasmatic reticulum-stress inducer used to study cardiovascular disease mechanisms. |
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| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vivo | A single or multiple doses of L-Homocystine administered to mice during organogenesis can aggravate the developmental disturbances caused by a single dose of VPA administered on GD 8. Whereas, VPA lowers significantly plasma FA and vitamin B12 concentrations, it has no direct impact on the homocysteine concentrations. Therefore, it is proposed that high levels of homocysteine disturb the FA, vitamin B12, and possibly methionine metabolism thus providing a favorable situation for VPA to interfere with the development of susceptible embryos[1]. |
| Animal Admin | Mice[1] Groups of mice are first injected on GD 8 with a single dose of 75 mg/kg of L-Homocystine or an equal volume of saline. One half of the L-Homocystine-treated animals then receive a single dose of 600 mg/kg of VPA ((H-HoCys-OH)2+VPA group), while the other half are injected with a proportionate volume of saline (L-Homocystine+saline group). In the other experiment, mice are treated with a daily dose of 75 mg/kg of L-Homocystine or a proportionate volume of saline starting from GD 5 and continue through GD 10. One half of the L-Homocystine-treated animals also have a single exposure to 600 mg/kg of VPA (L-Homocystine+VPA group) or a proportionate volume of saline (L-Homocystine+saline group) on GD 8. The total volume of fluid injected corresponded to the body weight and does not exceed 0.45 mL[1]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 507.6±50.0 °C at 760 mmHg |
| Melting Point | 281-284ºC (dec.) |
| Molecular Formula | C8H16N2O4S2 |
| Molecular Weight | 268.354 |
| Flash Point | 260.8±30.1 °C |
| Exact Mass | 268.055145 |
| PSA | 177.24000 |
| LogP | 1.03 |
| Vapour Pressure | 0.0±2.8 mmHg at 25°C |
| Index of Refraction | 1.619 |
| InChIKey | ZTVZLYBCZNMWCF-WDSKDSINSA-N |
| SMILES | NC(CCSSCCC(N)C(=O)O)C(=O)O |
| Storage condition | 2~8°C |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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L-Homocystine CAS#:626-72-2 |
| Literature: Miyazaki, Hideya; Ohta, Atsushi; Kawakatsu, Nobuyuki; Waki, Yukitaka; Gogun, Yasuhiro; et al. Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 2 p. 536 - 540 |
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L-Homocystine CAS#:626-72-2 |
| Literature: Biochemical Preparations, , vol. 5, p. 96 Journal of Biological Chemistry, , vol. 109, p. 97,101 |
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L-Homocystine CAS#:626-72-2
Learn More
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| Literature: Journal of Organic Chemistry, , vol. 57, # 1 p. 123 - 127 |
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L-Homocystine CAS#:626-72-2 |
| Literature: Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , # 4 p. 741 - 746 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 4 | |
|---|---|
| DownStream 10 | |
CAS#:14857-77-3
CAS#:63-68-3
CAS#:979-92-0
CAS#:13073-35-3
CAS#:13073-21-7
CAS#:1492-24-6
CAS#:73488-65-0
CAS#:764-52-3This table lists relevant public references with title, journal and publication metadata for this compound.
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Development of High-purity Certified Reference Materials for 17 Proteinogenic Amino Acids by Traceable Titration Methods.
Anal. Sci. 31 , 805-14, (2015) To ensure the reliability of amino acid analyses, the National Metrology Institute of Japan of the National Institute of Advanced Industrial Science and Technology (NMIJ/AIST) has developed high-purit... |
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Homocysteine Triggers Inflammatory Responses in Macrophages through Inhibiting CSE-H2S Signaling via DNA Hypermethylation of CSE Promoter.
Int. J. Mol. Sci. 16 , 12560-77, (2015) Hyperhomocysteinemia (HHcy) is an independent risk factor of atherosclerosis and other cardiovascular diseases. Unfortunately, Hcy-lowering strategies were found to have limited effects in reducing ca... |
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The species- and site-specific acid–base properties of biological thiols and their homodisulfides
J. Pharm. Biomed. Anal. 95 , 184-92, (2014) Cysteamine, cysteine, homocysteine, their homodisulfides and 9 related compounds were studied by ¹H NMR-pH titrations and case-tailored evaluation methods. The resulting acid-base properties are quant... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| L-Homocystine |
| Dl-Homocycine |
| (2S,2'S)-4,4'-Dithiobis(2-aminobutanoic acid) |
| dl-homocystine crystalline |
| HOMOCYSTINE,DL |
| QVYZ2SS2YZVQ &&L-L Form |
| (2S,2'S)-4,4'-Disulfanediylbis(2-aminobutanoic acid) |
| EINECS 210-962-5 |
| H-DL-Hcys-OH)2 |
| homocystine |
| (2S,2'S)-4,4'-Dithiobis(2-aminobutyric acid) |
| MFCD00020391 |
| DL-Homocystine |
| H-HoCys-OH |
| (H-HoCys-OH)2 |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the InChIKey of L-Homocystine? |
| A: InChIKey of L-Homocystine is ZTVZLYBCZNMWCF-WDSKDSINSA-N. |
| Q: What is the boiling point of L-Homocystine? |
| A: Boiling point of L-Homocystine is 507.6±50.0 °C at 760 mmHg. |
| Q: What is the polar surface area (PSA) of L-Homocystine? |
| A: Polar surface area (PSA) of L-Homocystine is 177.24000. |
| Q: What are the storage conditions for L-Homocystine? |
| A: Storage conditions for L-Homocystine: 2~8°C. |
| Q: What is the melting point of L-Homocystine? |
| A: Melting point of L-Homocystine is 281-284ºC (dec.). |
| Q: What are the downstream products of L-Homocystine? |
| A: Related downstream products(CAS) of L-Homocystine: 14857-77-3;63-68-3;979-92-0;6027-13-0;75027-08-6;13073-35-3;13073-21-7;1492-24-6;73488-65-0;764-52-3. |
| Q: What is the CAS number of L-Homocystine? |
| A: CAS number of L-Homocystine is 626-72-2. |
| Q: What are the upstream materials of L-Homocystine? |
| A: Related upstream materials(CAS) of L-Homocystine: 6027-13-0;7689-60-3;75027-08-6;139427-42-2. |
| Q: What is the LogP of L-Homocystine? |
| A: LogP of L-Homocystine is 1.03. |
| Q: What is the English name of L-Homocystine? |
| A: The English name of L-Homocystine is L-Homocystine. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Zhongshan Xingrui Chemical Co. , Ltd. |
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- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: L-Homocystine
- Price: Check
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- Zhongshan Xingrui Chemical Co. , Ltd.
- China
- Product Name: L-Homocystine
- Price: ￥Inquiry/25kg
- Purity: 99.0%
- Delivery: Inquiry
- Contact: Wang Jie
- Email: 3096638339@qq.com
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