Leucomycin A5

Modify Date: 2024-01-02 11:33:58

Leucomycin A5 Structure
Leucomycin A5 structure
Common Name Leucomycin A5
CAS Number 18361-45-0 Molecular Weight 771.93200
Density 1.22g/cm3 Boiling Point 871.4ºC at 760 mmHg
Molecular Formula C39H65NO14 Melting Point N/A
MSDS N/A Flash Point 480.8ºC

 Use of Leucomycin A5


Leucomycin a5 is a metabolite from the leucomycin complex, which was originally isolated from S. kitasatoensis. It is active against a variety of Gram-positive and Gram-negative bacteria (MICs = 0.04-0.8 μg/ml) but not against K. pneumoniae, S. typhimurium, or E. coli with MICs ranging from 5 to >10 μg/ml. Leucomycin A5 is also active against penicillin-susceptible and -resistant S. pyogenes (MICs = 0.8 and 3.2 μg/ml, respectively) and S. faecalis (MIC = 0.8 μg/ml).

 Names

Name [2,3'-Bi-1H-indole]-2',3-diol
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.22g/cm3
Boiling Point 871.4ºC at 760 mmHg
Molecular Formula C39H65NO14
Molecular Weight 771.93200
Flash Point 480.8ºC
Exact Mass 771.44100
PSA 199.98000
LogP 2.19660
Vapour Pressure 1.86E-35mmHg at 25°C
Index of Refraction 1.543

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OH4726170
CHEMICAL NAME :
Leucomycin V, 4(sup B)-butanoate
CAS REGISTRY NUMBER :
18361-45-0
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C39-H65-N-O14
MOLECULAR WEIGHT :
772.05

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3535309
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3535309

 Synonyms

leuco-indirubin
leucomycin A5
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