CL2A
Modify Date: 2025-08-24 19:04:32
CL2A structure
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Common Name | CL2A | ||
|---|---|---|---|---|
| CAS Number | 1846605-04-6 | Molecular Weight | 1106.22 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C51H79N9O18 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CL2ACL2A is a complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Labetuzumab govitecan used this linker[1]. |
| Name | CL2A |
|---|
| Description | CL2A is a complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Labetuzumab govitecan used this linker[1]. |
|---|---|
| Related Catalog | |
| Target |
Alkyl/ether |
| References |
[1]. Samantha Congreve, et al. Antibody drug conjugates (ADC). Teknisk- naturvetenskaplig fakultet |
| Molecular Formula | C51H79N9O18 |
|---|---|
| Molecular Weight | 1106.22 |
| InChIKey | ROPNJQCXVPLRBE-DBSIFAAZSA-N |
| SMILES | NCCCCC(NC(=O)COCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCn1cc(CNC(=O)C2CCC(CN3C(=O)C=CC3=O)CC2)nn1)C(=O)Nc1ccc(COC(=O)O)cc1 |