Ilorasertib hydrochloride
Modify Date: 2025-08-27 12:34:24
Ilorasertib hydrochloride structure
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Common Name | Ilorasertib hydrochloride | ||
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| CAS Number | 1847485-91-9 | Molecular Weight | 525.00 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H22ClFN6O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Ilorasertib hydrochlorideIlorasertib hydrochloride (ABT-348 hydrochloride) is a potent and ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A with IC50s of 1 nM, 7 nM, 120 nM, respectively. Ilorasertib hydrochloride (ABT-348 hydrochloride) also suppresses RET tyrosine kinase, PDGFRβ and Flt1 with IC50s of 7 nM, 3 nM and 32 nM, respectively[1]. |
| Name | Ilorasertib hydrochloride |
|---|
| Description | Ilorasertib hydrochloride (ABT-348 hydrochloride) is a potent and ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A with IC50s of 1 nM, 7 nM, 120 nM, respectively. Ilorasertib hydrochloride (ABT-348 hydrochloride) also suppresses RET tyrosine kinase, PDGFRβ and Flt1 with IC50s of 7 nM, 3 nM and 32 nM, respectively[1]. |
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| Related Catalog | |
| Target |
Aurora C:1 nM (IC50) Aurora B:7 nM (IC50) Aurora B (Y156H):12 nM (IC50) Aurora A:120 nM (IC50) PDGFRα:11 nM (IC50) PDGFRβ:13 nM (IC50) VEGFR1:1 nM (IC50) VEGFR2:2 nM (IC50) VEGFR3:43 nM (IC50) FLT3:1 nM (IC50) CSF-1R:3 nM (IC50) c-KIT:20 nM (IC50) |
| References |
| Molecular Formula | C25H22ClFN6O2S |
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| Molecular Weight | 525.00 |